3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide

Request For Quotation
3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide Suppliers list
Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
Tel: 18930552037
Email: 3bsc@sina.com
Company Name: BOC Sciences  
Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Company Name: Hangzhou Sage Chemical Co., Ltd.  
Tel: +86057186818502 13588463833
Email: info@sagechem.com
Company Name: Shanghai Lollane Biological Technology Co.,Ltd.  
Tel: 021-52996696，15000506266 15000506266
Email:
Company Name: EMMX Biotechnology LLC  
Tel: 888-539-0666
Email: info@emmx.com

3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide manufacturers

  • GR 46611
  • GR 46611 pictures
  • $84.00
  • 2026-09-10
  • CAS:185259-85-2
  • Purity: 99.90%
  • Supply Ability: 10g
3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide Basic information
Product Name:3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide
Synonyms:GR 46611;3-[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]-N-[(4-methoxyphenyl)methyl]prop-2-enamide;2-Propenamide, 3-[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]-N-[(4-methoxyphenyl)methyl]-;GR 46611, 5-HT1B/1D agonist;3-[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]-N-[(4-methoxyphenyl)methyl]-2-propenamide;3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide
CAS:185259-85-2
MF:C23H27N3O2
MW:377.48
EINECS:
Product Categories:
Mol File:185259-85-2.mol
3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide Structure
3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide Chemical Properties
Boiling point 645.9±55.0 °C(Predicted)
density 1.168
storage temp. 2-8°C
solubility DMSO: 28 mg/mL, soluble
pka14.51±0.46(Predicted)
form solid
color white
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide Usage And Synthesis
UsesGR 46611is a 5-HT1D agonist.
DefinitionChEBI: 3-[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]-N-[(4-methoxyphenyl)methyl]-2-propenamide is a member of tryptamines.
Biological Activity5-HT 1D receptor agonist. Blockade of GR 46611-induced hypothermia in the guinea pig provides a useful model with which to study the potency and duration of action of centrally acting 5-HT 1D receptor ligands.
in vivo

GR-46611 (1 mg/kg, i.p. ) significantly improves survival of Dravet syndrome (DS) mice[1].
GR-46611 (0.03-300 μg/kg, i.v.) increases threshold volume, bladder capacity, and residual volume in chronic spinal cord injury (SCI) cats[3].
GR46611 (3-30 mg/kg, s.c.) causes a dose-related decrease in rectal temperature in the adult guinea-pig[4].

Animal Model:Dravet syndrome (DS) mice[1]
Dosage:0.01, 0.1 and 1 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Improved survival relative to vehicle treated controls with 89% surviving rate.
IC 505-HT1D Receptor
3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide Preparation Products And Raw materials
Tag:3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide(185259-85-2) Related Product Information
3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide 5-Methyl-N,N-dimethyltryptamine FTBMT BU 224 hydrochloride Piribedil N-Oxide ACP-105