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PREGNENOLONE SULFATE SODIUM SALT manufacturers
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| | PREGNENOLONE SULFATE SODIUM SALT Basic information |
| Product Name: | PREGNENOLONE SULFATE SODIUM SALT | | Synonyms: | PREGNENOLONE SULFATE SODIUM;PREGNENOLONE SULFATE SODIUM SALT;Pregnenolone monosulfate sodium salt;(3β)-3-(Sulfooxy)-pregn-5-en-20-one sodium salt;PREGNENOLONE SULPHATE, SODIUM SALT;3B-HYDROXY-5-PREGNEN-20-ONE 3-SULFATE SODIUM SALT;3-BETA-HYDROXY-5-PREGNEN-20-ONE 3-SULPHATE, SODIUM SALT;3-HYDROXYPREGN-5-EN-20-ONE SULFATE SODIUM SALT | | CAS: | 1852-38-6 | | MF: | C21H32O5S.Na | | MW: | 419.53 | | EINECS: | | | Product Categories: | Steroids | | Mol File: | 1852-38-6.mol |  |
| | PREGNENOLONE SULFATE SODIUM SALT Chemical Properties |
| Melting point | 192 °C(lit.) | | storage temp. | Store at -20°C | | solubility | methanol and water: 1.93 mg/mL | | form | A crystalline solid | | color | White to off-white | | InChIKey | ABFNHVDDMHKJKK-WRHGONFGSA-N | | SMILES | [Na].[H][C@@]12CC=C3C[C@H](CC[C@]3(C)[C@@]1([H])CC[C@]4(C)[C@H](CC[C@@]24[H])C(C)=O)OS(O)(=O)=O |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | PREGNENOLONE SULFATE SODIUM SALT Usage And Synthesis |
| Description | Pregnenolone sulfate is a metabolite of the natural steroid hormone pregnenolone . Pregnenolone sulfate modulates NMDA receptor responses to exogenously applied glutamate and stimulates transient receptor potential melastatin 3 (TRPM3). | | Uses | Pregnenolone sulfate sodium salt has been used as sigma-1 receptor (σ1R) agonist. It has also been used in the stimulation and as a ligand for transient receptor potential melastatin-3 (TRPM3). | | Uses | Pregnenolone Sulfate Sodium Salt, is a metabolite of Pregnenolone (P712200). It is also a neuroactive steroid, a potent and efficacious modulators of the GABAA receptor. | | Biochem/physiol Actions | Pregnenolone sulfate is a neurosteroid and a neuromodulator. It is involved in the stimulation of N-methyl-D-aspartate receptor (NMDA), γ-Aminobutyric acid type A (GABAA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA-kainate). It activates transient receptor potential melastatin (TRPM3) which is a calcium-permeable ion channel. It improves schizophrenia and behavioral anomalies by modulating NMDA mediated Ser/Thr kinase - glycogen synthase kinase 3 β (AKT/GSK3β) signaling pathway. | | in vivo | Pregnenolone administration (2-6 mg/kg) blocks THC-induced food-intake in Wistar rats and in C57BL/6N mice, and blunts the memory impairment induced by THC in mice, but it does not modify these behaviors per se. Injections of Pregnenolone (2 and 4mg/kg) before each self-administration session reduce the intake of WIN 55,212-2 and reduce the break-point in a progressive ratio schedule[1]. | | IC 50 | CB1; Human Endogenous Metabolite | | storage | Store at +4°C | | References | [1] M SEDLáCEK. Neurosteroid modulation of ionotropic glutamate receptors and excitatory synaptic transmission.[J]. Physiological research, 2008, 57 Suppl 3: S49-S57. DOI: 10.33549/physiolres.931600
[2] CONOR C SMITH David H F Terrell T Gibbs. Pregnenolone sulfate as a modulator of synaptic plasticity.[J]. Psychopharmacology, 2014, 231 17: 3537-3556. DOI: 10.1007/s00213-014-3643-x
[3] GERALD THIEL Oliver G R Isabelle Müller. Signal transduction via TRPM3 channels in pancreatic β-cells.[J]. Journal of molecular endocrinology, 2013, 50 3: R75-83. DOI: 10.1530/jme-12-0237 |
| | PREGNENOLONE SULFATE SODIUM SALT Preparation Products And Raw materials |
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Tag:PREGNENOLONE SULFATE SODIUM SALT(1852-38-6)
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PREGNENOLONE SULFATE SODIUM SALT
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