S-(4-Nitrobenzyl)-6-thioinosine

S-(4-Nitrobenzyl)-6-thioinosine Suppliers list

Company Name:	3B Pharmachem (Wuhan) International Co.,Ltd.
Tel:	18930552037
Email:	3bsc@sina.com

Company Name:	Wuhu Huaren Science and Technology Co., Ltd.
Tel:	5842013 18155347026
Email:	xujuan@hdpharm.com

Company Name:	Chemsky（shanghai）International Co.,Ltd.
Tel:	021-50135380
Email:	shchemsky@sina.com

S-(4-Nitrobenzyl)-6-thioinosine manufacturers

S-(4-Nitrobenzyl)-6-thioinosine Basic information

Product Name:	S-(4-Nitrobenzyl)-6-thioinosine
Synonyms:	S-(P-NITROBENZYL)-6-THIOINOSINE;NBMPR;4-nitrobenzylthioinosine;6-(((4-nitrophenyl)methyl)thio)-9-beta-d-ribofuranosyl-9h-purin;6-(((4-nitrophenyl)methyl)thio)-9-beta-d-ribofuranosyl-9h-purine;6-(p-nitrobenzylthio)inosine;6-[(4-NITROBENZYL)THIO]-9-BETA-D-RIBOFURANOSYLPURINE;S-(4-NITROBENZYL)-6-THIOINOSINE (NBTI) P OTENT ADENOSINE UPTA
CAS:	38048-32-7
MF:	C17H17N5O6S
MW:	419.41
EINECS:	253-753-4
Product Categories:	Bases & Related Reagents;Heterocycles;Inhibitors;Nucleotides;Sulfur & Selenium Compounds
Mol File:	38048-32-7.mol

S-(4-Nitrobenzyl)-6-thioinosine Chemical Properties

Melting point	187-190 °C(lit.)
Boiling point	770.2±70.0 °C(Predicted)
density	1.3904 (rough estimate)
refractive index	1.6460 (estimate)
storage temp.	2-8°C
solubility	0.1 M HCl: slightly soluble
form	solid
pka	13.08±0.70(Predicted)
color	white
InChIKey	DYCJFJRCWPVDHY-LSCFUAHRSA-N
SMILES	OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(SCc4ccc(cc4)[N+]([O-])=O)ncnc23
CAS DataBase Reference	38048-32-7(CAS DataBase Reference)

Safety Information

MSDS Information

Provider	Language
ACROS	English
SigmaAldrich	English

S-(4-Nitrobenzyl)-6-thioinosine Usage And Synthesis

Chemical Properties	Off-White Solid
Uses	It is a prototype inhibitor of the human equilibrative nucleoside transporter (hENT1), and is a high affinity ligand with a Kd of 0.1-1.0 nM. Nucleoside transporter inhibitors have potential therapeutic applications as anticancer, antiviral, cardio
Uses	S-(4-Nitrobenzyl)-6-thioinosine is a nucleoside analog and an inhibitor of the human equilibrative nucleoside transporter (hENT1) (1,2,3). Nucleoside transporter inhibitors are useful compounds to investigate anticancer, antiviral, cardioprotective, and neuroprotective agents.
Definition	ChEBI: NBMPR is a purine nucleoside.
General Description	S-(4-Nitrobenzyl)-6-thioinosine (NBTI) belongs to the family of S⁶-substituted 6-thiopurine nucleosides, which regulate nucleoside transport mechanisms in animals. It acts as a ligand of adenosine transporter. Binding sites for NBTI is located on brain capillaries. It functions as a covalent photoaffinity probe for nucleoside transport.
Biological Activity	Equilibrative nucleoside transporter 1 (ENT1) inhibitor (K i values are 0.4 and 2800 nM for hENT1 and hENT2 respectively).
Biochem/physiol Actions	Inhibitor of equilibrative nucleoside transporters (ENTs), particularly adenosine transporters, in central nervous system and vascular smooth muscle.
storage	Store at +4°C

S-(4-Nitrobenzyl)-6-thioinosine Preparation Products And Raw materials

Raw materials

Tag:S-(4-Nitrobenzyl)-6-thioinosine(38048-32-7) Related Product Information

S-(p-Nitrobenzyl)-6-thioinosine, [3H]- 6-[(4-Nitrobenzyl)thio]-9-beta-D-ribofuranosylpurine-5'-monophosphate, disodium salt S-(4-Nitrobenzyl)-6-thioinosine S-(2-Hydroxy-5-nitrobenzyl)-6-thioinosine Nitrobenzylthioinosine, [benzyl-3H]- NBTGR