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| | N-BOC-AMINO-PIPERIDINYL-1,1-CARBOXYLIC ACID Basic information |
| Product Name: | N-BOC-AMINO-PIPERIDINYL-1,1-CARBOXYLIC ACID | | Synonyms: | N-BOC-AMINO-PIPERIDINYL-1,1-CARBOXYLIC ACID;N-(TERT-BUTOXYCARBONYL)-AMINO-PIPERIDINYL-1,1-CARBOXYLIC ACID;N-BOC-Amino-piperidinyl-1,1-carboxylic acid,95%;4-(tert-butoxycarbonyl)piperidine-4-carboxylic acid;4-(Boc-aMino)piperidine-4-carboxylic Acid;2-{[(tert-butoxy)carbonyl]aMino}piperidine-1-carboxylic acid;4-[[(tert-butoxyl)carbonyl]amino]-4-piperidinecarboxylic acid;4-[(2-methylpropan-2-yl)oxycarbonylamino]piperidine-4-carboxylic acid | | CAS: | 252720-31-3 | | MF: | C11H20N2O4 | | MW: | 244.29 | | EINECS: | | | Product Categories: | | | Mol File: | 252720-31-3.mol |  |
| | N-BOC-AMINO-PIPERIDINYL-1,1-CARBOXYLIC ACID Chemical Properties |
| Boiling point | 410℃ | | density | 1.18 | | refractive index | 1.4620 (estimate) | | Fp | 202℃ | | storage temp. | 2-8°C(protect from light) | | pka | 3.36±0.20(Predicted) | | Appearance | White to off-white Solid | | InChI | InChI=1S/C11H20N2O4/c1-10(2,3)17-9(16)13-11(8(14)15)4-6-12-7-5-11/h12H,4-7H2,1-3H3,(H,13,16)(H,14,15) | | InChIKey | RAENIWWUAIMXSI-UHFFFAOYSA-N | | SMILES | N1CCC(NC(OC(C)(C)C)=O)(C(O)=O)CC1 |
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ACROS
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| | N-BOC-AMINO-PIPERIDINYL-1,1-CARBOXYLIC ACID Usage And Synthesis |
| Chemical Properties | White to off-white crystalline powder | | Uses | N-Boc-amino-piperidinyl-1,1-carboxylic acid is used in pharmaceutical synthesis.
| | Synthesis | The synthesis of N-BOC-amino-piperidinyl-1,1-carboxylic acid usually starts with piperidine-4-carboxylic acid. Sodium bicarbonate and di-tert-butyl dicarbonate (Boc₂O) are added to the reaction system, and the amino protection reaction is carried out in a solvent such as tetrahydrofuran (THF) or 1,4-dioxane. The reaction is stirred at room temperature for several hours until the reaction is completed. Subsequently, the crude product is obtained by steps such as ethyl acetate extraction, pH adjustment of the aqueous phase, drying of the organic phase and reduced pressure concentration, and then purified by column chromatography using a mixed solvent of ethyl acetate and n-hexane as an eluent to finally obtain a high-purity target compound. |
| | N-BOC-AMINO-PIPERIDINYL-1,1-CARBOXYLIC ACID Preparation Products And Raw materials |
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