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N-Phenyl-9z-octadecenamide manufacturers
- Oleyl Anilide
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2025-12-22
- CAS:5429-85-6
- Purity:
- Supply Ability: 10g
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| | N-Phenyl-9z-octadecenamide Basic information |
| Product Name: | N-Phenyl-9z-octadecenamide | | Synonyms: | (Z)-N-phenyloctadec-9-enamide;(9Z)-N-Phenyl-9-octadecenamide;(Z)-N-(Phenyl)-9-octadecenamide;(Z)-N-Phenyl-9-octadecenamide;N-Phenyloleinamide;(z)-n-phenyl-9-octadeceneamide;oleanilide;oleoylanilide | | CAS: | 5429-85-6 | | MF: | C24H39NO | | MW: | 357.57 | | EINECS: | 2265849 | | Product Categories: | | | Mol File: | 5429-85-6.mol |  |
| | N-Phenyl-9z-octadecenamide Chemical Properties |
| Melting point | 41°C | | Boiling point | 490.17°C (rough estimate) | | density | 0.9837 (rough estimate) | | refractive index | 1.6000 (estimate) | | storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml | | form | A crystalline solid |
| | N-Phenyl-9z-octadecenamide Usage And Synthesis |
| Uses | Oleyl anilide (Oleic acid anilide) is a toxic agent found in some stocks of toxic oil, which is associated with toxic oil syndrome (TOS). Oleyl anilide is an inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT) (IC50: 26 μM)[1][2]. | | Definition | ChEBI: The fatty amide resulting from the formal condensation of oleic acid and aniline. | | in vivo | Oleyl anilide (0.8 mmol/kg, i.p., twice a week for 6 weeks) induces perturbations in the immune response, and lead to TOS-related immune derangements in female MRL+/+ mice[1].
| Animal Model: | Female MRL+/+ mice[2] | | Dosage: | 0.8 mmol/kg | | Administration: | i.p., twice a week for 6 weeks | | Result: | Increaseed IgG, IgG1, IgG2a, IgG3, IgE and IgG2b levels.
Increased lymphocyte population. |
| | References | [1] Roth BD, et al. Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Identification and structure-activity relationships of a novel series of fatty acid anilide hypocholesterolemic agents. J Med Chem. 1992 May 1;35(9):1609-17. DOI:10.1021/jm00087a016
[2] Cai P, et al. Immunotoxic response of oleic acid anilide and its hydrolysis products in female MRL (+/+) mice. J Immunotoxicol. 2005 Oct 1;2(4):231-6. DOI:10.1080/15476910500362960 |
| | N-Phenyl-9z-octadecenamide Preparation Products And Raw materials |
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