| Company Name: |
Sigma-Aldrich |
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021-61415566 800-8193336 |
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orderCN@merckgroup.com |
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| | MARGATOXIN Basic information | | Uses |
| Product Name: | MARGATOXIN | | Synonyms: | MARGATOXIN;MARGATOXIN, RECOMBINANT;MARGATOXIN (SCORPION);RMGTX;RMARGATOXIN;SCORPION VENOM CENTRUROIDES SCULPTURATUS;MGTX;MGTX (SCORPION) | | CAS: | 145808-47-5 | | MF: | C178H286N52O50S7 | | MW: | 4178.94884 | | EINECS: | | | Product Categories: | | | Mol File: | 145808-47-5.mol |  |
| | MARGATOXIN Chemical Properties |
| storage temp. | -20°C | | form | Powder | | color | White to off-white | | Water Solubility | Soluble to 0.50 mg/ml in water | | Sequence | Thr-Ile-Ile-Asn-Val-Lys-Cys-Thr-Ser-Pro-Lys-Gln-Cys-Leu-Pro-Pro-Cys-Lys-Ala-Gln-Phe-Gly-Gln-Ser-Ala-Gly-Ala-Lys-Cys-Met-Asn-Gly-Lys-Cys-Lys-Cys-Tyr-Pro-His (Disulfide bridge:Cys7-Cys29;Cys13-Cys34;Cys17-Cys36) | | InChIKey | OVJBOPBBHWOWJI-UHFFFAOYSA-N |
| Safety Statements | 22 | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | MARGATOXIN Usage And Synthesis |
| Uses | Margatoxin is a highly pure, synthetic, and biologically active peptide toxin. | | Uses | Biochemical probe. | | Uses | Margatoxin, Recombinant is a specific blocker of Kv1.3, Kv1.6 channels. | | Biochem/physiol Actions | Margatoxin is an α-KTx toxin, which is majorly used in ion channel research. It is a 39-amino acid peptide, which is a specific K(V)1.3 channel voltage-dependent K+ channel blocker. Margatoxin is an immunosuppressant that is isolated from the venom of the scorpion Centruroides margaritatus. | | in vivo | Margatoxin (i.p.; 1 pmol/g) significantly decreases thiogycollate-induced leukocyte transmigration in the peritoneal cavity in 12-week-old C57BL6/J mice[2]. | | storage | -20°C |
| | MARGATOXIN Preparation Products And Raw materials |
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