- 12-Crown-4
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2025-01-07
- CAS:294-93-9
- Purity: 99%
- Supply Ability: 100KG
- 12-Crown-4
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- $15.00
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2021-07-02
- CAS:294-93-9
- Min. Order: 1KG
- Purity: 99%+ HPLC
- 12-Crown-4
-
- $7.00
-
2019-07-06
- CAS: 294-93-9
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 100KG
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| | 12-Crown-4 Basic information |
| | 12-Crown-4 Chemical Properties |
| Melting point | 16 °C (lit.) | | Boiling point | 61-70 °C/0.5 mmHg (lit.) | | density | 1.089 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.463(lit.) | | Fp | >230 °F | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | form | Liquid After Melting | | Specific Gravity | 1.115 (20℃) | | color | Clear colorless to slightly yellow | | Water Solubility | MISCIBLE | | Sensitive | Air Sensitive | | BRN | 1363064 | | InChI | 1S/C8H16O4/c1-2-10-5-6-12-8-7-11-4-3-9-1/h1-8H2 | | InChIKey | XQQZRZQVBFHBHL-UHFFFAOYSA-N | | SMILES | C1COCCOCCOCCO1 | | CAS DataBase Reference | 294-93-9(CAS DataBase Reference) | | NIST Chemistry Reference | 12-Crown-4(294-93-9) | | EPA Substance Registry System | 1,4,7,10-Tetraoxacyclododecane (294-93-9) |
| Hazard Codes | T+,Xn,Xi | | Risk Statements | 26-36/37/38-20/21/22 | | Safety Statements | 28-36/37-45-36-26 | | RIDADR | UN 2810 | | WGK Germany | 3 | | RTECS | XF0550000 | | F | 3-9-23 | | TSCA | TSCA listed | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 29329995 | | Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | | Hazard Classifications | Acute Tox. 1 Inhalation | | Toxicity | LD50 oral in rat: 2830mg/kg |
| | 12-Crown-4 Usage And Synthesis |
| Chemical Properties | clear colorless to slightly yellow liquid after | | Uses | It serves as an aprotic "solvent" for alkali metals, the sodium solution is a strong reducing agent. | | Uses | 12-Crown-4 can be used as:
- A promoter in the synthesis of poly(diethylsiloxane) (PDES) from monomer hexaethylcyclotrisiloxane using NaOH as a catalyst via anionic ring-opening polymerization.
- As an additive in the preparation of triarylmethane derivatives by palladium-catalyzed cross coupling reaction of aryl bromides with diarylmethane derivatives.
- A phase transfer catalyst in organic synthesis.
| | Definition | ChEBI: A crown ether that is cyclododecane in which the carbon atoms at positions 1, 4, 7 and 10 have been replaced by oxygen atoms. | | Synthesis Reference(s) | Tetrahedron Letters, 15, p. 4029, 1974 DOI: 10.1016/S0040-4039(01)92075-1 | | General Description | 12-Crown-4 is a crown ether generally used as a ligand in coordination chemistry. It is also known as lithium ionophore because of its strong chelating property specific to lithium cation. | | Purification Methods | The distilled crude product has to be recrystallised from pentane at -20o to remove acyclic material. It is then dried over P2O5. It complexes Li. [Anet et al. Acta Chem Scand 27 3395 1973, Beilstein 19/11 V 334.] |
| | 12-Crown-4 Preparation Products And Raw materials |
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