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| | (S)-5-Amino-piperidin-2-one HCl Basic information | | Application |
| Product Name: | (S)-5-Amino-piperidin-2-one HCl | | Synonyms: | 4-(S)-AMINO-D-VALEROLACTAM HCL;(S)-5-AMINOPIPERIDIN-2-ONE HYDROCHLORIDE;2-Piperidinone, 5-amino-, monohydrochloride, (5S)-;(S)-5-AMINO-PIPERIDIN-2-ONEHCL (MFCD03094719);(S)-4-Amino-delta-valerolactam hydrochloride;(5S)-5-Aminopiperidin-2-one . x hydrochloride;(5S)-5-aminopiperidin-2-one hydrochloride;(S)-5-AMINO-PIPERIDIN-2-O | | CAS: | 672883-95-3 | | MF: | C5H11ClN2O | | MW: | 150.61 | | EINECS: | | | Product Categories: | pharmacetical | | Mol File: | 672883-95-3.mol |  |
| | (S)-5-Amino-piperidin-2-one HCl Chemical Properties |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | solid | | color | White |
| Hazard Codes | Xn | | Risk Statements | 22 | | HS Code | 2933399990 |
| | (S)-5-Amino-piperidin-2-one HCl Usage And Synthesis |
| Application | (S)-5-amino-piperidin-2-one hydrochloride is an organic intermediate that can be prepared from L-glutamic acid-5-methyl ester through a six-step reaction. | | Synthesis | Starting with L-glutamic acid-5-methyl ester, it was first reacted with di-tert-butyl dicarbonate in a triethylamine/DMF system at 50°C for 1 hour, then incubated overnight at room temperature. Column chromatography yielded a Boc-protected intermediate. This intermediate was dissolved in THF, reduced at -10°C with N-methylmorpholine, ethyl chloroformate, and sodium borohydride, quenched with saturated ammonium chloride, and purified by extraction to obtain a hydroxyl intermediate. This hydroxyl intermediate was then reacted with p-toluenesulfonyl chloride and triethylamine in dichloromethane at room temperature, and column chromatography yielded a sulfonyloxy intermediate. Subsequently, it was heated with sodium azide in DMF at 50°C for 3 hours to purify an azide intermediate. The azide intermediate was dissolved in methanol and hydrogenated overnight under atmospheric pressure using a 10% palladium/carbon catalyst. The solvent was removed by filtration to obtain a cyclization product. Finally, the cyclization product was dissolved in ethanol, and acetyl chloride was added at 0°C. The mixture was stirred at room temperature for 1 hour, and the solvent was removed under reduced pressure to obtain (S)-5-amino-piperidin-2-one hcl. |
| | (S)-5-Amino-piperidin-2-one HCl Preparation Products And Raw materials |
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