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| | TCO-PEG8-TCO Basic information |
| Product Name: | TCO-PEG8-TCO | | Synonyms: | TCO-PEG8-TCO;5,8,11,14,17,20,23,26-Octaoxa-2,29-diazatriacontanedioic acid, 1,30-di-4-cycloocten-1-yl ester | | CAS: | 2353409-67-1 | | MF: | C36H64N2O12 | | MW: | 716.9 | | EINECS: | | | Product Categories: | | | Mol File: | 2353409-67-1.mol |  |
| | TCO-PEG8-TCO Chemical Properties |
| Boiling point | 765.3±60.0 °C(Predicted) | | density | 1.13±0.1 g/cm3(Predicted) | | solubility | Soluble in DMSO, DCM, DMF | | pka | 11.65±0.46(Predicted) |
| | TCO-PEG8-TCO Usage And Synthesis |
| Description | TCO-PEG8-TCO is a PEG reagent containing TCO moiety at both ends of the molecule. TCO group specifically and efficiently reacts with tetrazine. The hydrophilic PEG8 arm increases the solubility of compounds in aqueous media. | | Uses | TCO-PEG8-TCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb;10(2):207-238. DOI:10.1016/j.apsb.2019.08.001 |
| | TCO-PEG8-TCO Preparation Products And Raw materials |
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