| Company Name: |
Daicel Chiral Technologies (China)CO.,LTD
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| Tel: |
021-50460086-9 15921403865 |
| Email: |
han_yajun@dctc.daicel.com |
| Products Intro: |
Product Name:6-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]hexanoic Acid
CAS:2087490-48-8
Purity:95% Package:250MG;1G Remarks:209714
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| Company Name: |
Shanghai YuanYe Biotechnology Co., Ltd.
|
| Tel: |
15026964105 |
| Email: |
2881489226@qq.com |
| Products Intro: |
Product Name:Thalidomide 4'-ether-alkylC5-acid
CAS:2087490-48-8
Purity:>=95%(HPLC) Package:100mg Remarks:S57278
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Thalidomide-O-C5-acid manufacturers
- Thalidomide-O-C5-acid
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2025-06-07
- CAS:2087490-48-8
- Min. Order: 500mg
- Purity: >98.00%
- Supply Ability: 500mg
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| | Thalidomide-O-C5-acid Basic information |
| Product Name: | Thalidomide-O-C5-acid | | Synonyms: | Hexanoic acid, 6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-;Thalidomide 4'-ether-alkylC5-acid;Thalidomide-O-C5-acid;6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)hexanoic acid;PUN 90488;6-[2-(2,6-dioxoazaperhydroin-3-yl)-1,3-dioxobenzo[c]azolin-4-yloxy]hexanoic acid;Thalidomide-4-O-C5-COOH;6-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]hexanoic Acid | | CAS: | 2087490-48-8 | | MF: | C19H20N2O7 | | MW: | 388.37 | | EINECS: | | | Product Categories: | | | Mol File: | 2087490-48-8.mol |  |
| | Thalidomide-O-C5-acid Chemical Properties |
| Boiling point | 694.4±55.0 °C(Predicted) | | density | 1.423±0.06 g/cm3(Predicted) | | pka | 4.73±0.10(Predicted) | | form | Solid | | color | White to off-white |
| | Thalidomide-O-C5-acid Usage And Synthesis |
| Description | PUN 90488, also known as Thalidomide 4'-ether-alkylC5-acid is a cereblon ligand with alkyl linker and terminal acid for onward chemistry. This product has no formal name at the moment. | | Uses | Thalidomide-O-C5-acid is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. | | IC 50 | Cereblon | | storage | Store at -20°C | | References | [1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1008. DOI:10.1016/j.cell.2020.07.024 |
| | Thalidomide-O-C5-acid Preparation Products And Raw materials |
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