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| | 4-(2,2,2-Trifluoroethoxy)phenylboronic acid Basic information |
| Product Name: | 4-(2,2,2-Trifluoroethoxy)phenylboronic acid | | Synonyms: | 4-(2,2,2-Trifluoroethoxy)benzeneboronic acid;4-(2,2,2-Trifluoroethoxy)benzeneboronic acid 98%;4-(2,2,2-Trifluoroethoxy)benzeneboronicacid98%;(4-(2,2,2-Trifluoroethoxy);Boronic acid, B-[4-(2,2,2-trifluoroethoxy)phenyl]-;4-(2,2,2-trifluoroethoxy)phenyboronic acid;4-(2,2,2-Trifluoroethoxy)benzeneboronic acid, [4-(2,2,2-Trifluoroethoxy)phenyl]boronic acid;4-(2,2,2-Trifluoroethoxy)phenylboronic acid | | CAS: | 886536-37-4 | | MF: | C8H8BF3O3 | | MW: | 219.95 | | EINECS: | | | Product Categories: | Boronate Ester;Boronic Acid;Potassium Trifluoroborate;blocks;BoronicAcids;FluoroCompounds | | Mol File: | 886536-37-4.mol |  |
| | 4-(2,2,2-Trifluoroethoxy)phenylboronic acid Chemical Properties |
| Melting point | 191-194℃ | | Boiling point | 297.1±50.0 °C(Predicted) | | density | 1.35±0.1 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | solid | | pka | 8.58±0.16(Predicted) | | color | White | | InChI | InChI=1S/C8H8BF3O3/c10-8(11,12)5-15-7-3-1-6(2-4-7)9(13)14/h1-4,13-14H,5H2 | | InChIKey | DWRAMTYYMNLVBD-UHFFFAOYSA-N | | SMILES | B(C1=CC=C(OCC(F)(F)F)C=C1)(O)O |
| Hazard Codes | Xi | | Hazard Note | Irritant | | HS Code | 2931900090 |
| | 4-(2,2,2-Trifluoroethoxy)phenylboronic acid Usage And Synthesis |
| Uses | 4-(2,2,2-Trifluoroethoxy)phenylboronic acid can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process. | | Synthesis | 2- (2,2,2-trifluoroethoxy) bromobenzene 2558, isopropyl borate 2448 and methylTetrahydrofuran 1.5L was added to the reaction flask, and the reaction system was cooled to -15 ° C. 500 mL of isopropylmagnesium chloride in tetrahydrofuran (2.0 M) was added dropwise to the above reaction system and the internal temperature was controlled to not more than -10 ° C, and the reaction was kept at a low temperature for 1 hour. After completion of the reaction, 500 mL of 6M aqueous hydrochloric acid solution was added to terminate the reaction and the ρH- = 2 ~ 3 was added, and the mixture was thoroughly stirred and the aqueous phase was extracted with methyltetrahydrofuran (1.5 LX 1). The combined organic layers were washed with saturated brine (1.5 LX 2), and the combined organic layers were dried over anhydrous sodium sulfate and concentrated to give the crude product of 2- (2,2,2-trifluoroethoxy) phenylboronic acid. The crude product was recrystallized from 770 mL of isopropanol and water (10: 1 by volume) to give 187 g of 2- (2,2,2-trifluoroethoxy) phenylboronic acid in a molar yield of 85%. |
| | 4-(2,2,2-Trifluoroethoxy)phenylboronic acid Preparation Products And Raw materials |
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