2,4-Heptadienamide, 6-[(1R,3aS,4E,7aR)-4-[2-[(3R,5R)-3,5-dihydroxycyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-N-hydroxy-4-methyl-, (2E,4E,6R)-

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2,4-Heptadienamide, 6-[(1R,3aS,4E,7aR)-4-[2-[(3R,5R)-3,5-dihydroxycyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-N-hydroxy-4-methyl-, (2E,4E,6R)- Basic information
Product Name:2,4-Heptadienamide, 6-[(1R,3aS,4E,7aR)-4-[2-[(3R,5R)-3,5-dihydroxycyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-N-hydroxy-4-methyl-, (2E,4E,6R)-
Synonyms:2,4-Heptadienamide, 6-[(1R,3aS,4E,7aR)-4-[2-[(3R,5R)-3,5-dihydroxycyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-N-hydroxy-4-methyl-, (2E,4E,6R)-;Triciferol
CAS:957214-00-5
MF:C26H39NO4
MW:429.59
EINECS:
Product Categories:
Mol File:957214-00-5.mol
2,4-Heptadienamide, 6-[(1R,3aS,4E,7aR)-4-[2-[(3R,5R)-3,5-dihydroxycyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-N-hydroxy-4-methyl-, (2E,4E,6R)- Structure
2,4-Heptadienamide, 6-[(1R,3aS,4E,7aR)-4-[2-[(3R,5R)-3,5-dihydroxycyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-N-hydroxy-4-methyl-, (2E,4E,6R)- Chemical Properties
density 1.214±0.06 g/cm3(Predicted)
storage temp. 4°C, protect from light, stored under nitrogen
form Solid
pka8.98±0.23(Predicted)
color White to off-white
Safety Information
MSDS Information
2,4-Heptadienamide, 6-[(1R,3aS,4E,7aR)-4-[2-[(3R,5R)-3,5-dihydroxycyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-N-hydroxy-4-methyl-, (2E,4E,6R)- Usage And Synthesis
Description

Triciferol functions as a multiple ligand with combined VDR agonist and HDAC antagonist activities. Triciferol binds directly to the VDR (IC50=87 nM), and functions as an agonist with 1,25D-like potency on several 1,25D target genes. Triciferol induces marked tubulin hyperacetylation, and augments histone acetylation. Antiproliferative and cytotoxic activities[1].

Triciferol (0-10000 nM; 0-72 hours) is significantly more efficacious in suppressing the proliferation of estrogen receptor-negative human MDA-MB231 breast cancer cells[1].Treatment of MCF-7 cells with Triciferol (100-1000 nM) induces ≈2.5-fold higher rates of cell death than equimolar amounts of 1,25D[1].

UsesTriciferol functions as a multiple ligand with combined VDR agonist and HDAC antagonist activities. Triciferol binds directly to the VDR (IC50=87 nM), and functions as an agonist with 1,25D-like potency on several 1,25D target genes. Triciferol induces marked tubulin hyperacetylation, and augments histone acetylation. Antiproliferative and cytotoxic activities[1].
References

[1]. Tavera-Mendoza LE, et al. Incorporation of histone deacetylase inhibition into the structure of a nuclear receptor agonist. Proc Natl Acad Sci U S A. 2008;105(24):8250-8255.

2,4-Heptadienamide, 6-[(1R,3aS,4E,7aR)-4-[2-[(3R,5R)-3,5-dihydroxycyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-N-hydroxy-4-methyl-, (2E,4E,6R)- Preparation Products And Raw materials
Tag:2,4-Heptadienamide, 6-[(1R,3aS,4E,7aR)-4-[2-[(3R,5R)-3,5-dihydroxycyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-N-hydroxy-4-methyl-, (2E,4E,6R)-(957214-00-5) Related Product Information
2,4-Heptadienamide, 6-[(1R,3aS,4E,7aR)-4-[2-[(3R,5R)-3,5-dihydroxycyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-N-hydroxy-4-methyl-, (2E,4E,6R)- Calcitriol Carbamazepine [4-[(Hydroxyamino)carbonyl]phenyl]carbamic acid [6-[(diethylamino)methyl]-2-naphthalenyl]methyl ester N-[2-Methyl-2-(2-phenyloxazol-4-yl)propyl]-3-[5-(trifluoroMethyl)-1,2,4-oxadiazol-3-yl]benzaMide Entinostat