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| | 5-Methoxy-isobenzofuran-1,3-dione Basic information |
| Product Name: | 5-Methoxy-isobenzofuran-1,3-dione | | Synonyms: | 5-Methoxy-1,3-dihydro-2-benzofuran-1,3-dione;METHYL N-(DIPHENYLMETHYLENE)-L-SERINATE;1,3-Isobenzofurandione, 5-methoxy-;5-Methoxy-2-benzofuran-1,3-dione;5-Methoxy-isobenzofuran-1,3-dione;5-Methoxy-isobenzofuran-1;5-Methoxy-1,3-isobenzofurandione | | CAS: | 28281-76-7 | | MF: | C9H6O4 | | MW: | 178.14 | | EINECS: | | | Product Categories: | | | Mol File: | 28281-76-7.mol |  |
| | 5-Methoxy-isobenzofuran-1,3-dione Chemical Properties |
| Melting point | 98-99 °C(Solv: acetic acid (64-19-7)) | | Boiling point | 348.6±25.0 °C(Predicted) | | density | 1.407±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | Appearance | White to light yellow Solid |
| | 5-Methoxy-isobenzofuran-1,3-dione Usage And Synthesis |
| Uses | 5-Methoxyisobenzofuran-1,3-dione is used as a reagent in the synthesis of basic ethers of 1,2-dihydropyrrolo[1,2-α]indole, 6H-isoindolo[2,1-α]indole, and 6H-benz[5,6]isoindolo[2,1-α]indole which display antiproliferative activity. | | Synthesis | The general procedure for the synthesis of 5-methoxyisobenzofuran-1,3-dione using 4-methoxyphthalic acid as starting material was as follows: acetic anhydride (40 mL) was slowly added to a solution of anhydrous tetrahydrofuran (150 mL) containing 4-methoxyphthalic acid (30.8 g, 0.16 mol). The reaction mixture was refluxed with stirring for 4 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the solvent was subsequently evaporated under reduced pressure to afford 4-methoxyphthalic anhydride (27.8 g, 99% yield) as an off-white solid. The structure of the product was confirmed by 1H NMR (DMSO-d6): δ 8.02 (1H, d), 7.59 (1H, d), 7.49 (1H, dd), 3.97 (3H, s). Mass spectrometry analysis showed the [M + H]+ peak at 179. | | References | [1] Patent: WO2008/44029, 2008, A1. Location in patent: Page/Page column 204
[2] Patent: WO2008/44041, 2008, A1. Location in patent: Page/Page column 225-226
[3] Patent: WO2008/44045, 2008, A1. Location in patent: Page/Page column 277-278
[4] Patent: WO2008/44054, 2008, A2. Location in patent: Page/Page column 122
[5] Patent: US2010/152184, 2010, A1. Location in patent: Page/Page column 72; 73 |
| | 5-Methoxy-isobenzofuran-1,3-dione Preparation Products And Raw materials |
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