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lucanthone manufacturers
- Lucanthone
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- $51.00
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2026-09-10
- CAS:479-50-5
- Purity: 99.92%
- Supply Ability: 10g
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| | lucanthone Basic information |
| Product Name: | lucanthone | | Synonyms: | lucanthone;1-[[2-(Diethylamino)ethyl]amino]-4-methyl-9H-thioxanthen-9-one;Lycanthone;1-(2-diethylaminoethylamino)-4-(methyl)thioxanthen-9-one;Lucanthonum;Lucantona;9H-Thioxanthen-9-one, 1-[[2-(diethylamino)ethyl]amino]-4-methyl-;Autophagy,inhibit,Lucanthone,Inhibitor | | CAS: | 479-50-5 | | MF: | C20H24N2OS | | MW: | 340.48 | | EINECS: | 207-532-4 | | Product Categories: | | | Mol File: | 479-50-5.mol |  |
| | lucanthone Chemical Properties |
| Melting point | 64.5°C | | Boiling point | 512.4±50.0 °C(Predicted) | | density | 1.0915 (rough estimate) | | refractive index | 1.5950 (estimate) | | storage temp. | Store at -20°C | | solubility | DMSO : 25 mg/mL (73.43 mM) | | form | Solid | | pka | 10.00±0.25(Predicted) | | color | Off-white to orange |
| | lucanthone Usage And Synthesis |
| Uses | Lucanthone is an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1). | | Definition | ChEBI: Lucanthone is a thioxanthen-9-one compound having a methyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. Formerly used for the treatment of schistosomiasis. It is a prodrug, being metabolised to hycanthone. It has a role as a schistosomicide drug, an antineoplastic agent, a photosensitizing agent, an EC 5.99.1.2 (DNA topoisomerase) inhibitor, an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor, a prodrug, an adjuvant and a mutagen. | | Safety Profile | Poison by intravenous
route. Human mutation data reported.
When heated to decomposition it emits very
toxic fumes of NOx and SOx. | | References | [1] Chowdhury SM, et al. Graphene nanoribbons as a drug delivery agent for lucanthone mediated therapy of glioblastoma multiforme. Nanomedicine. 2015 Jan;11(1):109-18. DOI:10.1016/j.nano.2014.08.001
[2] Carew JS, et al. Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. J Biol Chem. 2011 Feb 25;286(8):6602-13. DOI:10.1074/jbc.M110.151324 |
| | lucanthone Preparation Products And Raw materials |
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