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Sigma-Aldrich |
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021-61415566 800-8193336 |
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orderCN@merckgroup.com |
| Company Name: |
BOC Sciences |
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| Product Name: | BTO-1 | | Synonyms: | BTO-1;5-Cyano-7-nitro-2-benzothiazolecarboxamide-3-oxide;Polo-like Kinase Inhibitor II, BTO-1;Polo-like Kinase Inhibitor II, BTO-1 - CAS 40647-02-7 - Calbiochem;2-Benzothiazolecarboxamide, 5-cyano-7-nitro-, 3-oxide | | CAS: | 40647-02-7 | | MF: | C9H4N4O4S | | MW: | 264.22 | | EINECS: | | | Product Categories: | | | Mol File: | 40647-02-7.mol |  |
| | BTO-1 Chemical Properties |
| Boiling point | 553.0±60.0 °C(Predicted) | | density | 1.89±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | H2O: <2ML/mL | | form | solid | | pka | 14.67±0.30(Predicted) | | color | tan | | Water Solubility | H2O: <2mL/mL
DMSO: ≥5mg/mL | | InChI | 1S/C9H4N4O4S/c10-3-4-1-5-7(6(2-4)13(16)17)18-9(8(11)14)12(5)15/h1-2H,(H2,11,14) | | InChIKey | FKRBAXZAJBBIAJ-UHFFFAOYSA-N | | SMILES | NC(=O)c1sc2c(cc(cc2[n+]1[O-])C#N)[N+]([O-])=O |
| | BTO-1 Usage And Synthesis |
| Uses | BTO-1 is a benzothiazolo-N-oxide Plk1 inhibitor. | | General Description | A cell-permeable benzothiazolo-N-oxide compound that targets the ATP-binding pocket of polo-like kinase and is shown to inhibit Plk1 kinase activity in cell-free kinase assays (IC50 = 8.0 μM) and suppress the phosphorylation of cellular Plk1 substrate Cdc25C in rat kangaroo kidney-derived PTK cells (75% inhibition at 6.3 μM). BTO-1 treatment of cultured cells results in mitosis defects consistent with loss-of-Plk1 phenotypes seen in Plk1 RNAi-treated U20S cells, including the appearance of monopolar spindles and the reduction of γ-tubulin at the centrosomes. Plk1 inhibition by BTO-1 in HeLa cells results in a blockage of Rho and Rho-GEF recruitment, which is essential for the assembly of a functional contractile ring. | | Biochem/physiol Actions | BTO-1 is a polo-like kinase (Plk) inhibitor. | | IC 50 | Plx1 |
| | BTO-1 Preparation Products And Raw materials |
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