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| | CROSSTIDE Basic information |
| Product Name: | CROSSTIDE | | Synonyms: | Glycine, glycyl-L-arginyl-L-prolyl-L-arginyl-L-threonyl-L-seryl-L-seryl-L-phenylalanyl-L-alanyl-L-a-glutaMyl-;Glycine, glycyl-L-arginyl-L-prolyl-L-arginyl-L-threonyl-L-seryl-L-seryl-L-phenylalanyl-L-alanyl-L-α-glutamyl-;Crosstide >=97% (HPLC), lyophilized powder;(6S,9S,12S,15S,18S,21S,24S)-1-amino-6-((S)-1-((S)-2-(2-aminoacetamido)-5-guanidinopentanoyl)pyrrolidine-2-carboxamido)-18-benzyl-24-(2-carboxyethyl)-9-((R)-1-hydroxyethyl)-12,15-bis(hydroxymethyl)-1-imino-21-methyl-7,10,13,16,19,22,25-heptaoxo-2,8,11,14,17,20,23,26-octaazaoctacosan-28-oic acid;Crosstide [GRPRTSSFAEG] - 5 mg | | CAS: | 171783-05-4 | | MF: | C48H77N17O17 | | MW: | 1164.23 | | EINECS: | | | Product Categories: | Protein Kinase B (Akt/PKB)Peptides for Cell Biology;Protein Kinase Related Peptides;Protein Kinase Substrates;Serine/Threonine Kinase Biology;Serine/Threonine Kinase Substrates | | Mol File: | 171783-05-4.mol |  |
| | CROSSTIDE Chemical Properties |
| storage temp. | −20°C | | solubility | H2O: soluble | | form | lyophilized powder | | color | White to off-white | | Sequence | Gly-Arg-Pro-Arg-Thr-Ser-Ser-Phe-Ala-Glu-Gly |
| | CROSSTIDE Usage And Synthesis |
| Uses | Crosstide is a peptide analog of glycogen synthase kinase α/β fusion protein sequence which is a substrate for Akt. | | References | [1] Bentley JK, et al. Rhinovirus activates interleukin-8 expression via a Src/p110beta phosphatidylinositol 3-kinase/Akt pathway in human airway epithelial cells. J Virol. 2007 Feb;81(3):1186-94. Epub 2006 Nov 22. DOI:10.1128/JVI.02309-06
[2] Baer K, et al. Activation of a GST-tagged AKT2/PKBbeta. Biochim Biophys Acta. 2005 Oct 10;1725(3):340-7. Epub 2005 Apr 20. DOI:10.1016/j.bbagen.2005.04.002 |
| | CROSSTIDE Preparation Products And Raw materials |
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