Spiro[2H-1-benzothiopyran-3(4H),1'-cyclopropan]-4-one, 2'-(4-methoxyphenyl)-, (1'R,2'R)-rel- manufacturers
- CYT296
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2026-05-11
- CAS:1799392-31-6
- Purity:
- Supply Ability: 10g
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| | Spiro[2H-1-benzothiopyran-3(4H),1'-cyclopropan]-4-one, 2'-(4-methoxyphenyl)-, (1'R,2'R)-rel- Basic information |
| Product Name: | Spiro[2H-1-benzothiopyran-3(4H),1'-cyclopropan]-4-one, 2'-(4-methoxyphenyl)-, (1'R,2'R)-rel- | | Synonyms: | Spiro[2H-1-benzothiopyran-3(4H),1'-cyclopropan]-4-one, 2'-(4-methoxyphenyl)-, (1'R,2'R)-rel-;CYT296;rel-(1R,2R)-2-(4-Methoxyphenyl)spiro[cyclopropane-1,3'-thiochroman]-4'-one;(1S,2S)-2-(4-methoxyphenyl)spiro[cyclopropane-1,3'-thiochroman]-4'-one;(2'S,3S)-2'-(4-methoxyphenyl)spiro[2H-thiochromene-3,1'-cyclopropane]-4-one;CYT296|1799392-31-6|HY-141591|CS-0182033 | | CAS: | 1799392-31-6 | | MF: | C18H16O2S | | MW: | 296.39 | | EINECS: | | | Product Categories: | | | Mol File: | 1799392-31-6.mol | ![Spiro[2H-1-benzothiopyran-3(4H),1'-cyclopropan]-4-one, 2'-(4-methoxyphenyl)-, (1'R,2'R)-rel- Structure](CAS/20210305/GIF/1799392-31-6.gif) |
| | Spiro[2H-1-benzothiopyran-3(4H),1'-cyclopropan]-4-one, 2'-(4-methoxyphenyl)-, (1'R,2'R)-rel- Chemical Properties |
| Boiling point | 474.9±45.0 °C(Predicted) | | density | 1.29±0.1 g/cm3(Predicted) | | form | Oil | | color | White to off-white |
| | Spiro[2H-1-benzothiopyran-3(4H),1'-cyclopropan]-4-one, 2'-(4-methoxyphenyl)-, (1'R,2'R)-rel- Usage And Synthesis |
| Uses | CYT296 is a target chromatin de-condensation compound. CYT296 can improve the induction of induced pluripotent stem cell (iPSCs) mediated by defined factors (OSKM) and induce an open chromatin state in Mouse Embryonic Fibroblast (MEFs) to facilitate somatic cell reprogramming. CYT296 can be used for cell replacement therapies and drug screening research[1]. | | in vivo | CYT296 (10-15 4F- and 2F -iPSC clones for subcutaneous injection, once) generates the iPSCs are pluripotent in the NOD-SCID mice[1].
| Animal Model: | 4F- and 2F-iPSC clones mice[1] | | Dosage: | 10-15 4F- and 2F -iPSC clones | | Administration: | Subcutaneous injection (s.c.) | | Result: | Obtained 6 out of 10 born mice from clone 4F-1 and 9 out of 15 born mice from clone 2F-1 were chimeras. |
| | References | [1] Wei X, et al. Small molecule compound induces chromatin de-condensation and facilitates induced pluripotent stem cell generation. J Mol Cell Biol. 2014 Oct;6(5):409-20. DOI:10.1093/jmcb/mju024 |
| | Spiro[2H-1-benzothiopyran-3(4H),1'-cyclopropan]-4-one, 2'-(4-methoxyphenyl)-, (1'R,2'R)-rel- Preparation Products And Raw materials |
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