1H-Pyrazol-5-ol, 1-(5-methyl-2-pyridinyl)-3-phenyl- manufacturers
- COQ7-IN-2
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- $198.00
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2026-07-14
- CAS:2579696-76-5
- Purity: 99.84%
- Supply Ability: 10g
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| | 1H-Pyrazol-5-ol, 1-(5-methyl-2-pyridinyl)-3-phenyl- Basic information |
| | 1H-Pyrazol-5-ol, 1-(5-methyl-2-pyridinyl)-3-phenyl- Chemical Properties |
| Boiling point | 480.4±45.0 °C(Predicted) | | density | 1.22±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 25 mg/mL (99.49 mM; Need ultrasonic) | | pka | 7.15±0.50(Predicted) | | form | Solid | | color | White to off-white |
| | 1H-Pyrazol-5-ol, 1-(5-methyl-2-pyridinyl)-3-phenyl- Usage And Synthesis |
| Uses | COQ7-IN-2 (compound 12) is an inhibitor of COQ7, witn IC50 values of 7.3 μM and 15.4 μM for DMQ10 and UQ10 accumulation, respectively[1]. | | Biological Activity | COQ7-IN-2 (compound 12) is an inhibitor of COQ7, witn IC50 values of 7.3 μM and 15.4 μM for DMQ10 and UQ10 accumulation, respectively[1].
COQ7-IN-2 (compound 12) has less growth inhibition against human normal culture cells[1].The substantial DMQ10 accumulation occurred in both PANC-1 cells (8.7% by COQ7-IN-2 (compound 12)) and PC3 cells (14.0% by COQ7-IN-2 (compound 12))[1]. | | References | [1]. Keiko Tsuganezawa, et al. Identification of small molecule inhibitors of human COQ7. Bioorg Med Chem. 2020 Jan 1;28(1):115182. |
| | 1H-Pyrazol-5-ol, 1-(5-methyl-2-pyridinyl)-3-phenyl- Preparation Products And Raw materials |
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