APX-115 freebase manufacturers
- APX-115 free base
-
- $42.00
-
2026-08-14
- CAS:1270084-92-8
- Purity: 99.03%
- Supply Ability: 10g
- APX-115 free base
-
- $42.00
-
2026-08-14
- CAS:1270084-92-8
- Purity: 99.03%
- Supply Ability: 10g
- APX-115 free base
-
- $42.00
-
2025-05-12
- CAS:1270084-92-8
- Purity: 99.03%
- Supply Ability: 10g
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| | APX-115 freebase Basic information |
| Product Name: | APX-115 freebase | | Synonyms: | APX-115 freebase;Ewha-18278 free base;1H-Pyrazol-5-ol, 3-phenyl-4-propyl-1-(2-pyridinyl)-;3-Phenyl-4-propyl-1-(pyridin-2-yl)-1H-pyrazol-5-ol;plasma,APX 115 free base,NOX,Inhibitor,injury,Nox1,kidney,Ewha18278,APX115,albumin,Ewha 18278,APX115 free base,insulin,Ewha-18278,Nox3,resistance,APX 115,APX-115,NADPH Oxidase,inhibit,creatinine,Nox2;Isuzinaxib(APX-115 free base);APX-115 free base, 10 mM in DMSO;Apx-115 free | | CAS: | 1270084-92-8 | | MF: | C17H17N3O | | MW: | 279.34 | | EINECS: | | | Product Categories: | | | Mol File: | 1270084-92-8.mol |  |
| | APX-115 freebase Chemical Properties |
| Boiling point | 493.3±45.0 °C(Predicted) | | density | 1.17±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: Sparingly Soluble: 1-10 mg/ml
Ethanol: Sparingly Soluble: 1-10 mg/ml | | pka | 7+-.0.50(Predicted) | | form | Solid | | color | Light yellow to yellow |
| | APX-115 freebase Usage And Synthesis |
| Uses | APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base effectively prevents kidney injury[1]. | | in vivo | APX-115 free base (oral gavage; 60mg/kg/day; for 12 weeks) significantly improves insulin resistance in diabetic mice[2].
APX-115 free base treatment decreases the urinary excretion of albumin and plasma creatinine levels[2].
| Animal Model: | Six-week-old male diabetic db/db mice (C57BLKS/J-leprdb/leprdb)[2] | | Dosage: | 60mg/kg | | Administration: | Oral gavage; per day; for 12 weeks | | Result: | Significantly improved insulin resistance in diabetic mice.
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| | IC 50 | NOX1; NOX2; NOX4 | | References | [1] Kwon G, et al. A novel pan-Nox inhibitor, APX-115, protects kidney injury in streptozotocin-induced diabetic mice: possible role of peroxisomal and mitochondrial biogenesis. Oncotarget. 2017 Jun 16;8(43):74217-74232. DOI:10.18632/oncotarget.18540
[2] Cha JJ, et al. APX-115, a first-in-class pan-NADPH oxidase (Nox) inhibitor, protects db/db mice from renal injury. Lab Invest. 2017 Apr;97(4):419-431. DOI:10.1038/labinvest.2017.2
[3] J. JOO. A novel pyrazole derivative protects from ovariectomy-induced osteoporosis through the inhibition of NADPH oxidase[J]. Scientific Reports, 2016, 6 1. DOI: 10.1038/srep22389 |
| | APX-115 freebase Preparation Products And Raw materials |
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