| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
Methanone, [4-[5-amino-6-[4-(trifluoromethyl)phenyl]-2-pyrazinyl]phenyl](4-hydroxy-1-piperidinyl)- manufacturers
- MMV666810
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- $2500.00
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2026-07-14
- CAS:1450666-97-3
- Purity: 99.96%
- Supply Ability: 10g
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| | Methanone, [4-[5-amino-6-[4-(trifluoromethyl)phenyl]-2-pyrazinyl]phenyl](4-hydroxy-1-piperidinyl)- Basic information |
| | Methanone, [4-[5-amino-6-[4-(trifluoromethyl)phenyl]-2-pyrazinyl]phenyl](4-hydroxy-1-piperidinyl)- Chemical Properties |
| Boiling point | 593.5±50.0 °C(Predicted) | | density | 1.364±0.06 g/cm3(Predicted) | | pka | 14.49±0.20(Predicted) |
| | Methanone, [4-[5-amino-6-[4-(trifluoromethyl)phenyl]-2-pyrazinyl]phenyl](4-hydroxy-1-piperidinyl)- Usage And Synthesis |
| Description | MMV666810 is a novel inhibitor of Plasmodium falciparum gametocytes. | | Uses | MMV666810, a 2-aminopyrazine similar to MMV390048, is potent against asexual parasites at 5.94 nM, but against gametocytes, it has a 3.3-fold selectivity to late-stage gametocytes compared to earlier stages (early-stage gametocyte: IC50 603 ± 88 nM; late-stage gametocyte: IC50 179 ± 8 nM). | | References | [1] Niemand J, et al. Chemogenomic Fingerprints Associated with Stage-Specific Gametocytocidal Compound Action against Human Malaria Parasites. ACS Infect Dis. 2021 Oct 8;7(10):2904-2916. DOI:10.1021/acsinfecdis.1c00373 |
| | Methanone, [4-[5-amino-6-[4-(trifluoromethyl)phenyl]-2-pyrazinyl]phenyl](4-hydroxy-1-piperidinyl)- Preparation Products And Raw materials |
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