Dibenzo[b,f]thiepin-10-ol, 1-chloro-, 10,10'-(hydrogen phosphate), sodium salt (1:1)

Dibenzo[b,f]thiepin-10-ol, 1-chloro-, 10,10'-(hydrogen phosphate), sodium salt (1:1) manufacturers

Dibenzo[b,f]thiepin-10-ol, 1-chloro-, 10,10'-(hydrogen phosphate), sodium salt (1:1) Basic information

Product Name:	Dibenzo[b,f]thiepin-10-ol, 1-chloro-, 10,10'-(hydrogen phosphate), sodium salt (1:1)
Synonyms:	Dibenzo[b,f]thiepin-10-ol, 1-chloro-, 10,10'-(hydrogen phosphate), sodium salt (1:1);GPR84 antagonist 2
CAS:	2244269-74-5
MF:	C28H18Cl2NaO4PS2
MW:	607.43
EINECS:
Product Categories:
Mol File:	2244269-74-5.mol

Dibenzo[b,f]thiepin-10-ol, 1-chloro-, 10,10'-(hydrogen phosphate), sodium salt (1:1) Chemical Properties

form	Solid
color	Off-white to light yellow

Safety Information

MSDS Information

Dibenzo[b,f]thiepin-10-ol, 1-chloro-, 10,10'-(hydrogen phosphate), sodium salt (1:1) Usage And Synthesis

Uses	GPR84 antagonist 2 (compound 33) is a potent, selective, and orally active GPR84 antagonist (IC50=8.95 nM). GPR84 antagonist 2 shows improved potency in the calcium mobilization assay and the ability to inhibit the chemotaxis of neutrophils and macrophages upon GPR84 activation. GPR84 antagonist 2 has the potential for the research of ulcerative colitis[1].
References	[1] Chen LH, et al. Phosphodiesters as GPR84 Antagonists for the Treatment of Ulcerative Colitis. J Med Chem. 2022;65(5):3991-4006. DOI:10.1021/acs.jmedchem.1c01813

Dibenzo[b,f]thiepin-10-ol, 1-chloro-, 10,10'-(hydrogen phosphate), sodium salt (1:1) Preparation Products And Raw materials

Tag:Dibenzo[b,f]thiepin-10-ol, 1-chloro-, 10,10'-(hydrogen phosphate), sodium salt (1:1)(2244269-74-5) Related Product Information

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