Carbamic acid, [(3R)-3-pyrrolidinylmethyl]-, 1,1-dimethylethyl ester (9CI) manufacturers
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| | Carbamic acid, [(3R)-3-pyrrolidinylmethyl]-, 1,1-dimethylethyl ester (9CI) Basic information |
| Product Name: | Carbamic acid, [(3R)-3-pyrrolidinylmethyl]-, 1,1-dimethylethyl ester (9CI) | | Synonyms: | Carbamic acid, [(3R)-3-pyrrolidinylmethyl]-, 1,1-dimethylethyl ester (9CI);(R)-3-N-Boc-aminomethylpyrrolidine;tert-Butyl (3R)-pyrrolidin-3-ylmethylcarbamate;R-3-N-Boc-aMinoMethypyrrolidine;tert-butyl N-[(3R)-pyrrolidin-3-ylmethyl]carbamate;(R)-1-pyrrolidin-3-ylmethylcarbamic acid tert-butyl ester;Carbamic acid, N-[(3R)-3-pyrrolidinylmethyl]-, 1,1-dimethylethyl ester;cc-000004 | | CAS: | 173340-25-5 | | MF: | C10H20N2O2 | | MW: | 200.28 | | EINECS: | | | Product Categories: | N-BOC | | Mol File: | 173340-25-5.mol | ![Carbamic acid, [(3R)-3-pyrrolidinylmethyl]-, 1,1-dimethylethyl ester (9CI) Structure](CAS/GIF/173340-25-5.gif) |
| | Carbamic acid, [(3R)-3-pyrrolidinylmethyl]-, 1,1-dimethylethyl ester (9CI) Chemical Properties |
| Boiling point | 303.9±15.0 °C(Predicted) | | density | 0.997±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 12.71±0.46(Predicted) | | Appearance | white solid |
| | Carbamic acid, [(3R)-3-pyrrolidinylmethyl]-, 1,1-dimethylethyl ester (9CI) Usage And Synthesis |
| Uses | (R)-tert-butyl pyrrolidin-3-ylmethylcarbamate is a useful reagent in the research discovery of ethyl 5,6-dihydropyrazolo[1,5-c]quinazoline-1-carboxylate, a catalytic inhibitor of DNA gyrase and a potential antibacterial agent. | | Synthesis | General procedure: tert-butyl (R)-(1-benzylpyrrolidin-3-ylmethyl)carbamate (1.00 g, 3.44 mmol) was mixed with 20% Pd/C and subjected to hydrogenation under hydrogen pressure of 50 psi.After 48 h, the reaction mixture was filtered to remove the catalyst, and the filtrate was concentrated to give 511 mg of tert-butyl (3R)-pyrrolidin-3-methylcarbamate ( Yield: 74%). Mass spectrometry analysis (APCI+): m/z 201 ([M + H]+). | | References | [1] Patent: WO2005/49602, 2005, A1. Location in patent: Page/Page column 87; 88; 121
[2] Patent: WO2005/49605, 2005, A1. Location in patent: Page/Page column 115; 116; 149 |
| | Carbamic acid, [(3R)-3-pyrrolidinylmethyl]-, 1,1-dimethylethyl ester (9CI) Preparation Products And Raw materials |
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