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2-Quinoxalinecarboxamide, N-(4-methoxyphenyl)- manufacturers
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| | 2-Quinoxalinecarboxamide, N-(4-methoxyphenyl)- Basic information |
| Product Name: | 2-Quinoxalinecarboxamide, N-(4-methoxyphenyl)- | | Synonyms: | 2-Quinoxalinecarboxamide, N-(4-methoxyphenyl)-;WAY-327157;5-HT3 antagonist 5;WAY327157,WAY 327157;N-(4-Methoxyphenyl)quinoxaline-2-carboxamide;N-(4-methoxyphenyl)-2-quinoxalinecarboxamide;5-HT3 antagonist 5, 10 mM in DMSO | | CAS: | 901599-43-7 | | MF: | C16H13N3O2 | | MW: | 279.29 | | EINECS: | | | Product Categories: | | | Mol File: | 901599-43-7.mol |  |
| | 2-Quinoxalinecarboxamide, N-(4-methoxyphenyl)- Chemical Properties |
| Melting point | 176-178 °C(Solv: ethanol (64-17-5); ethyl ether (60-29-7)) | | Boiling point | 393.2±32.0 °C(Predicted) | | density | 1.312±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 20.83 mg/mL (74.58 mM; ultrasonic and warming and heat to 60°C) | | pka | 11.07±0.70(Predicted) | | form | Solid | | color | Light yellow to yellow |
| | 2-Quinoxalinecarboxamide, N-(4-methoxyphenyl)- Usage And Synthesis |
| Uses | 5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound, a 5-HT3 receptor antagonist. 5-HT3 antagonist 5 exerts antagonism on 5-HT3 agonist and 2-methyl-5-HT, and shows anti-depressant effect in mice[1]. | | in vivo | 5-HT3 antagonist 5 (compound 4c) (1 mg/kg; i.p.; single dose) decreases the duration of immobility and shows anti-depressant effect in FST mice[1].
| Animal Model: | Swiss albino mice (23 ± 2 g)[1] | | Dosage: | 1 mg/kg | | Administration: | Intraperitoneal injection; single dose; locomotor scores tested 10 min after administration | | Result: | Reduced the duration of immobility as compared to the vehicle-treated (control) group.
Showed no effect on the locomotion of mice as observed in spontaneous locomotor activity. |
| | IC 50 | 5-HT3 Receptor | | References | [1] Mahesh R, et al. Design, synthesis and structure-activity relationship of novel quinoxalin-2-carboxamides as 5-HT3 receptor antagonists for the management of depression. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6773-6. DOI:10.1016/j.bmcl.2010.08.128 |
| | 2-Quinoxalinecarboxamide, N-(4-methoxyphenyl)- Preparation Products And Raw materials |
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