(S)- manufacturers
- MDL-101146, (S)-
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- $1670.00
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2026-05-11
- CAS:163660-59-1
- Purity:
- Supply Ability: 10g
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| Product Name: | (S)- | | Synonyms: | MDL-101146, (S)-;MDL101146, (S),MDL 101146, (S) | | CAS: | 163660-59-1 | | MF: | C29H37F5N4O6 | | MW: | 632.63 | | EINECS: | | | Product Categories: | | | Mol File: | 163660-59-1.mol |  |
| Uses | (S)-MDL-101146 is the S-isomer of MDL-101146. MDL-101146 is an orally active, competitive and reversible inhibitor against human neutrophil elastase (HNE) with a Ki value of 25 nM. MDL-101146 inhibits HNE-induced hemorrhage in hamsters. MDL-101146 is promising for research of emphysema, rheumatoid arthritis, chronic bronchitis, cystic fibrosis, adult respiratory distress syndrome and glomerulonephritis[1]. | | Definition | ChEBI: N-[4-(morpholin-4-ylcarbonyl)benzoyl]-L-valyl-N-[(3S)-5,5,6,6,6-pentafluoro-2-methyl-4-oxohexan-3-yl]-L-prolinamide is a N-acylpyrrolidine, a pyrrolidinecarboxamide, a member of morpholines, an organofluorine compound and a L-proline derivative. | | References | [1] Angelastro MR, et al. Inhibition of human neutrophil elastase with peptidyl electrophilic ketones. 2. Orally active PG-Val-Pro-Val pentafluoroethyl ketones. J Med Chem. 1994 Dec 23;37(26):4538-53. DOI:10.1021/jm00052a013 |
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