| Company Name: |
Sigma-Aldrich |
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
3'-DEPHOSPHOCOENZYME A manufacturers
- Dephospho-CoA
-
- $1090.00
-
2026-05-11
- CAS:3633-59-8
- Purity:
- Supply Ability: 10g
|
| | 3'-DEPHOSPHOCOENZYME A Basic information |
| | 3'-DEPHOSPHOCOENZYME A Chemical Properties |
| density | 1.85±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Water: 50 mg/ml | | form | A crystalline solid | | pka | 1.16±0.50(Predicted) | | color | White to off-white | | InChIKey | KDTSHFARGAKYJN-UHFFFAOYSA-N | | SMILES | CC(C)(COP(O)(=O)OP(O)(=O)OCC1OC(C(O)C1O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | 3'-DEPHOSPHOCOENZYME A Usage And Synthesis |
| Description | 3''-Dephosphocoenzyme A is an intermediate in the biosynthesis of coenzyme A (CoA; Item Nos. 16147 | 21499 | 21722) from pantothenic acid (vitamin B5; ). It is phosphorylated by CoA synthase in humans to form CoA. 3''-Dephosphocoenzyme A can be used as a transcription initiator in the synthesis of CoA-RNA by in vitro transcription. | | Uses | Dephosphocoenzyme A is the direct precursor of coenzyme A. It is used for the synthesis of coenzyme A by bifunctional CoA Synthase (CoASy, 4′-phosphopantetheine adenylyltransferase/dephospho-CoA kinase) which performs the transfer of the γ-phosphate of ATP to dephosphocoenzyme A. | | Definition | ChEBI: An adenosine 5'-phosphate that is coenzyme A in which the phosphate group at position 3' has been replaced by a hydrogen atom. It is an intermediate metabolite in pantothenate and CoA biosynthesis | | Biochem/physiol Actions | 3′-Dephosphocoenzyme A (DepCoA), also called desphosphoCoA (dpCoA), is synthesized from 4-phosphopantetheine by the enzyme phosphopanthetheine adenylyltransferase. It is an intermediate in coenzyme A biosynthetic pathway. In the presence of dephospho-CoA kinase (CoaE), dephosphocoenzyme A is converted to coenzyme A. 3′-Dephosphocoenzyme shares adenosine-diphosphate substructure as like the purines and is a non-canonical nucleotide and is an initiator of transcription initiation. It is routinely used in in vitro transcription studies to initiate RNA synthesis. | | IC 50 | Human Endogenous Metabolite | | References | [1] HUANG F. Efficient incorporation of CoA, NAD and FAD into RNA by in vitro transcription.[J]. Nucleic Acids Research, 2003, 31 3: e8. DOI: 10.1093/nar/gng008
[2] KRISHNA SAPKOTA Faqing H. Efficient one-pot enzymatic synthesis of dephospho coenzyme A[J]. Bioorganic Chemistry, 2018, 76: Pages 23-27. DOI: 10.1016/j.bioorg.2017.10.012 |
| | 3'-DEPHOSPHOCOENZYME A Preparation Products And Raw materials |
|