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Indinavir sulfate

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Indinavir sulfate Basic information
Product Name:Indinavir sulfate
Synonyms:CRIXIVAN;INDINAVIR SULFATE;INDINAVIR SULPHATE;(1(1s,2r),5(s))-2,3,5-trideoxy-n-(2,3-dihydro-2-hydroxy-1h-inden-1-yl)-5-(2-(((1,1-dimethylethyl)amino)carbonyl)-4-(3-pyridinylmethyl)-1-piperazinyl)-2-(phenylmethyl)-d-erythro-pentonamide sulfate;MK-639;indinavirsulfate(subjecttopatentfree);IDV;MK-639,Crixivan
CAS:157810-81-6
MF:C36H49N5O8S
MW:711.87
EINECS:682-418-9
Product Categories:Active Pharmaceutical Ingredients;Indinavir;peptides;Other APIs;Anti-viral Compounds;Anti-virals;Inhibitors;Intermediates & Fine Chemicals;Non-nucleoside Reverse Transcriptase;Pharmaceuticals;Coronavirus
Mol File:157810-81-6.mol
Indinavir sulfate Structure
Indinavir sulfate Chemical Properties
Melting point 150-153°C (dec)
storage temp. -20°C Freezer
solubility Freely soluble in water, soluble in methanol, practically insoluble in heptane.
form Solid
color White to Off-White
Water Solubility >100g/L(temperature not stated)
BCS Class2,4
Safety Information
Hazardous Substances Data157810-81-6(Hazardous Substances Data)
MSDS Information
Indinavir sulfate Usage And Synthesis
DescriptionIndinavir is an HIV-1 protease inhibitor (Ki = 0.358 nM). It is selective for HIV-1 protease over HIV-2 protease (Ki = 3.316 nM), as well as human cathepsin D, porcine pepsin, bovine chymosin, human plasma renin, Factor Xa, and elastase at 10 μM. It is also selective for wild-type HIV-1 protease over the protease inhibitor-resistant mutants A-44, K-60, and V-18 (Kis = 0.24, 15, 50, and 40 nM, respectively). Indinavir is active against multiple HIV-1 variants in cell-based assays (IC95s = 12-100 nM). Formulations containing indinavir have been used in combination with antiretroviral agents in the treatment of HIV infection.
Chemical PropertiesCrystalline Solid
UsesIndinavir Sulfate is a member of the novel hydroxyaminopentane amide class of HIV-1 protease inhibitors. Antiviral. It is a COVID19-related research product.
DefinitionChEBI: Indinavir sulfate is an azaheterocycle sulfate salt. It is functionally related to an indinavir.
Brand nameCrixivan (Merck).
HazardModerately toxic by ingestion.
storageRT
References[1] J P VACCA. L-735,524: an orally bioavailable human immunodeficiency virus type 1 protease inhibitor.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1994, 91 9: 4096-4100. DOI: 10.1073/pnas.91.9.4096
[2] BRUCE D. DORSEY. Identification of MK-944a: A Second Clinical Candidate from the Hydroxylaminepentanamide Isostere Series of HIV Protease Inhibitors[J]. Journal of Medicinal Chemistry, 2000, 43 18: 3386-3399. DOI: 10.1021/jm9903848
Indinavir sulfate Preparation Products And Raw materials
Tag:Indinavir sulfate(157810-81-6) Related Product Information
Zinc sulphate Barium sulfate Dimethyl sulfate Sodium thiosulfate pentahydrate Metformin Magnesium sulfate heptahydrate Ammonium sulfate Sodium sulfate Magnesium sulfate Dimethyl carbonate Dimethyl fumarate Dibutyl phthalate Dimethylamine Copper(II) sulfate Indinavir Aluminum sulfate Ferrous sulfate heptahydrate Chlorophosphonazo III