(4Z,7S,8S,9E,11E,13Z,15E,17S,19Z)-7,8,17-TRIHYDROXYDOCOSA-4,9,11,13,15,19-HEXAENOIC ACID CAS#: 872993-05-0

(4Z,7S,8S,9E,11E,13Z,15E,17S,19Z)-7,8,17-TRIHYDROXYDOCOSA-4,9,11,13,15,19-HEXAENOIC ACID

生物活性靶点体外研究体内研究用途与合成方法 MSDS (4Z,7S,8S,9E,11E,13Z,15E,17S,19Z)-7,8,17-TRIHYDROXYDOCOSA-4,9,11,13,15,19-HEXAENOIC ACID价格(试剂级) 上下游产品信息

中文名称	(4Z,7S,8S,9E,11E,13Z,15E,17S,19Z)-7,8,17-TRIHYDROXYDOCOSA-4,9,11,13,15,19-HEXAENOIC ACID
中文同义词	(4Z,7S,8R,9E,11E,13Z,15E,17S,19Z)-7,8,17-三羟基-4,9,11,13,15,19-二十二碳六烯酸;消退素D1;化合物 T13864;化合物 RESOLVIN D1
英文名称	(4Z,7S,9E,11E,13Z,15E,17S,19Z)-7,8,17-trihydroxydocosa-4,9,11,13,15,19-hexaenoic acid
英文同义词	(4Z,7S,9E,11E,13Z,15E,17S,19Z)-7,8,17-trihydroxydocosa-4,9,11,13,15,19-hexaenoic acid;(4Z,7S,8S,9E,11E,13Z,15E,17S,19Z)-7,8,17-TRIHYDROXYDOCOSA-4,9,11,13,15,19-HEXAENOIC ACID;resolvin D1, CID73755062;OIWTWACQMDFHJG-CCFUIAGSSA-N;Resolvin D1 Exclusive;4,9,11,13,15,19-Docosahexaenoic acid, 7,8,17-trihydroxy-, (4Z,7S,8R,9E,11E,13Z,15E,17S,19Z)-;Resolvin D1 MaxSpec? Standard;Resolvin D1,Resolvin D-1
CAS号	872993-05-0
分子式	C22H32O5
分子量	376.49
EINECS号
相关类别	试剂盒-细胞分析试剂盒
Mol文件	872993-05-0.mol
结构式

(4Z,7S,8S,9E,11E,13Z,15E,17S,19Z)-7,8,17-TRIHYDROXYDOCOSA-4,9,11,13,15,19-HEXAENOIC ACID 性质

沸点	609.240±55.00 °C(Press: 760.00 Torr)(predicted)
密度	1.102±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
储存条件	Store at -80°C,protect from light
溶解度	DMF：50 mg/ml；乙醇：50 mg/ml； PBS（pH 7.2）：0.05 mg/ml
形态	液体
酸度系数(pKa)	4.579±0.10(predicted)
颜色	无色至浅黄

(4Z,7S,8S,9E,11E,13Z,15E,17S,19Z)-7,8,17-TRIHYDROXYDOCOSA-4,9,11,13,15,19-HEXAENOIC ACID 用途与合成方法

生物活性

Resolvin D1 (RvD1) 是炎症的一种内源性促分解介质，衍生自在急性炎症的缓解阶段的 omega-3二十二碳六烯酸。Resolvin D1 通过调节肌动蛋白聚合来阻止促炎性中性粒细胞迁移，减少巨噬细胞中 TNF-α 介导的炎症，并增强巨噬细胞对凋亡细胞的吞噬作用。

靶点

Human Endogenous Metabolite

体外研究

Resolvin D1 (RvD1) (1-100 nM; 15 minutes) induces dose-dependent short-term functional changes in primary human macrophages. RvD1 triggers intracellular Ca ²⁺ release, blocks chemotactic migration, and stimulates phagocytosis of microbial particles with maximal efficiency at 10 nM. Resolvin D1 (0-500 nM; 72 hours) shows a strong inhibition of LPS-induced TRAP and cathepsin K expression by RvD1 at different concentrations in RAW264.7 macrophages.

体内研究

Resolvin D1 (RvD1) (100-1000 ng; i.p.; daily on days 10) improves RA (rheumatoid arthritis) clinical endpoints in arthritic mice.

Animal Model:	18-20 g thirty 8-week-old female DBA/1J mice (collagen antibody-induced arthritis (CAIA))
Dosage:	100, 500, and 1000 ng (or 1000 ng, daily on days 4-10)
Administration:	i.p. injection; daily on days 10
Result:	Exhibit a reduced arthritic score.

安全信息

MSDS信息

(4Z,7S,8S,9E,11E,13Z,15E,17S,19Z)-7,8,17-TRIHYDROXYDOCOSA-4,9,11,13,15,19-HEXAENOIC ACID 价格(试剂级)

更新日期	产品编号	产品名称	CAS号	包装	价格
2026/06/05	HY-125527	(4Z,7S,8S,9E,11E,13Z,15E,17S,19Z)-7,8,17-TRIHYDROXYDOCOSA-4,9,11,13,15,19-HEXAENOIC ACID Resolvin D1	872993-05-0	25μg(265.6μM * 250μL in Ethanol)	8500元

(4Z,7S,8S,9E,11E,13Z,15E,17S,19Z)-7,8,17-TRIHYDROXYDOCOSA-4,9,11,13,15,19-HEXAENOIC ACID