tert-Butyl 2-bromo-4-fluorobenzoate

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Company Name: Capot Chemical Co.,Ltd.
Tel: +86-（0）57185586718; +8613336195806
Email: sales@capot.com
Products Intro: Product Name:Tert-Butyl 4-bromo-2-fluorobenzoate
CAS:889858-12-2
Purity:98%(Min.GC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Beijing Cooperate Pharmaceutical Co.,Ltd
Tel: 010-60279497
Email: sales01@cooperate-pharm.com
Products Intro: Product Name:tert-butyl4-bromo-2-fluorobenzoate
CAS:889858-12-2
Purity:98%99% Package:100G;1KG;5KG;10KG;25KG;50KG;100KG
Company Name: Hi-Tech Chemistry Corp
Tel: 0519-86626038
Email: yuhh@hitechem.com
Products Intro: Product Name:tert-butyl 2-bromo-4-fluoro-benzoate
CAS:889858-12-2
Company Name: Shanghai Yingrui Biopharma Co., Ltd.
Tel: +86-21-33585366 - 03@
Email: sales03@shyrchem.com
Products Intro: Product Name:tert-Butyl 2-bromo-4-fluorobenzoate
CAS:889858-12-2
Purity:99% Package:100g;500g;1kg;25kg...
Company Name: Fluoropharm Co., Ltd.
Tel: +86-0571-85586753 +86-13336034509
Email: sales@fluoropharm.com
Products Intro: Product Name:4-Bromo-2-fluoro-benzoic acid tert-butyl ester
CAS:889858-12-2
Purity:0.98 Package:25KG;5KG;1KG Remarks:Mature product

tert-Butyl 2-bromo-4-fluorobenzoate manufacturers
tert-Butyl 2-bromo-4-fluorobenzoate Basic information
Product Name:tert-Butyl 2-bromo-4-fluorobenzoate
Synonyms:tert-Butyl 2-bromo-4-fluorobenzoate;4-Bromo-2-fluoro-benzoic acid tert-butyl ester;2-Methylpropan-2-yl 4-bromo-2-fluorobenzoate;Benzoic acid,4-bromo-2-fluoro-, 1,1-dimethylethyl ester;tera-butyl 4-Bromo-2-fluorobenzoate;tert-Butyl 2-fluoro-4-bromobenzoate
CAS:889858-12-2
MF:C11H12BrFO2
MW:275.11
EINECS:
Product Categories:
Mol File:889858-12-2.mol
tert-Butyl 2-bromo-4-fluorobenzoate Structure
tert-Butyl 2-bromo-4-fluorobenzoate Chemical Properties
Boiling point 305.7±27.0 °C(Predicted)
density 1.394±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility Chloroform (Slightly), Methanol (Slightly)
form Oil
color Clear Colourless
Safety Information
HS Code 2916399090
MSDS Information
tert-Butyl 2-bromo-4-fluorobenzoate Usage And Synthesis
Usestert-Butyl 4-Bromo-2-fluorobenzoate is an intermediate of enzalutamide (M199800). Enzalutamide is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. MDV 3100 has also been shown to induce tumor cell apoptosis, and has no agonist activity. MDV 3100 is a candidate for the treatment of castration-resistant prostate cancer.
References[1] Patent: WO2016/102482, 2016, A1. Location in patent: Page/Page column 114
[2] Patent: US9242996, 2016, B2. Location in patent: Page/Page column 248; 251
[3] Patent: WO2016/97004, 2016, A1. Location in patent: Page/Page column 108
tert-Butyl 2-bromo-4-fluorobenzoate Preparation Products And Raw materials
Raw materials4-Bromo-2-fluorobenzoic acid-->tert-Butanol-->Pyridine-->N,N-Dimethylformamide-->Dichloromethane-->Tetrahydrofuran-->Oxalyl chloride
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