| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:Cosalane
CAS:154212-56-3
Purity:98.00% Package:1mg;5mg;10mg
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| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:Cosalane
CAS:154212-56-3
Purity:99.53% Package:1mg/RMB 2880;5mg/RMB 6570;10mg/RMB 8530
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cosalane manufacturers
- Cosalane
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- $372.00
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2026-06-12
- CAS:154212-56-3
- Purity: 99.53%
- Supply Ability: 10g
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| | cosalane Basic information |
| Product Name: | cosalane | | Synonyms: | cosalane;Benzoic acid, 3,3'-[4-(3β,5α)-cholestan-3-yl-1-butenylidene]bis[5-chloro-6-hydroxy-;NSC 658586;NSC-658586;5-{4-[(1R,3aS,3bR,5aS,7S,9aS,9bS,11aR)-9a,11a-dimethyl-1-[(2R)-6-methylheptan-2-yl]-hexadecahydro-1H-cyclopenta[a]phenanthren-7-yl]-1-(3-carboxy-5-chloro-4-hydroxyphenyl)but-1-en-1-yl}-3-chloro-2-hydroxybenzoic acid | | CAS: | 154212-56-3 | | MF: | C45H60Cl2O6 | | MW: | 767.86 | | EINECS: | | | Product Categories: | | | Mol File: | 154212-56-3.mol |  |
| | cosalane Chemical Properties |
| Boiling point | 797.4±60.0 °C(Predicted) | | density | 1.191±0.06 g/cm3(Predicted) | | pka | 2.07±0.14(Predicted) | | form | Solid | | color | White to off-white | | Water Solubility | 1.4ug/L(temperature not stated) |
| | cosalane Usage And Synthesis |
| Uses | Cosalane (NSC 658586) is a potent inhibitor of HIV replication. Cosalane has an intrinsic ability to block human and murine CCR7 function in vitro in response to both of its natural ligands, CCL19 and CCL21, with the IC50 of 0.207/2.66 μM in human for CCL19/CCL21 and 0.193/1.98 μM in murine, respectively[1][2]. | | IC 50 | Human CCR7; Murine CCR7 | | References | [1] Kenneth A Fowler, et al. The Ex Vivo Treatment of Donor T Cells with Cosalane, an HIV Therapeutic and Small-Molecule Antagonist of CC-Chemokine Receptor 7, Separates Acute Graft-versus-Host Disease from Graft-versus-Leukemia Responses in Murine Hematopoietic Stem Cell Transplantation Models. Biol Blood Marrow Transplant. 2019 Jun;25(6):1062-1074. DOI:10.1016/j.bbmt.2019.01.022
[2] Emily A Hull-Ryde, et al. Identification of Cosalane as an Inhibitor of Human and Murine CC-Chemokine Receptor 7 Signaling via a High-Throughput Screen. SLAS Discov. 2018 Dec;23(10):1083-1091. DOI:10.1177/2472555218780917 |
| | cosalane Preparation Products And Raw materials |
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