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| | TAK 024 Basic information |
| Product Name: | TAK 024 | | Synonyms: | TAK 024;1-Piperazineacetic acid, 4-[2-[[4-[(aminoiminomethyl)amino]benzoyl]amino]acetyl]-3-[3-[[4-[(aminoiminomethyl)amino]benzoyl]amino]propyl]-2-oxo-, (3S)-;TAK 024,TAK024 | | CAS: | 186971-69-7 | | MF: | C27H34N10O6 | | MW: | 594.62 | | EINECS: | | | Product Categories: | | | Mol File: | 186971-69-7.mol |  |
| | TAK 024 Chemical Properties |
| Melting point | 245-251.5 °C | | density | 1.51±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 3.66±0.10(Predicted) |
| | TAK 024 Usage And Synthesis |
| Uses | TAK-024 is a platelet inhibitor with IC50s of 31, 79 and 51 nM in human, monkey and guinea pig, respectively. | | in vivo | Intravenous infusion of TAK-024 (compound 12c) at 1.6 μg/mL/min completely prevents arterial thrombus formation induced by endothelial injury in guinea pigs. Results demonstrate the inhibitory effects of TAK-024 on the carotid thrombosis induced by balloon injury in guinea pigs and the ID50 value is 0.73 μg/kg/min. A single dose of TAK-024 at 100 μg/kg iv produces almost complete inhibition for 120 min, and about 40% inhibition is observed after 240 min. Dose-dependent inhibition of platelet aggregation is achieved with a single iv dose of 30 to 100 μg/kg of TAK-024[1]. | | References | [1] Kitamura S, et al. Potent dibasic GPIIb/IIIa antagonists with reduced prolongation of bleeding time: synthesis and pharmacological evaluation of 2-oxopiperazine derivatives. J Med Chem. 2001 Jul 19;44(15):2438-50. DOI:10.1021/jm0004345 |
| | TAK 024 Preparation Products And Raw materials |
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