| Company Name: |
BOC Sciences |
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CI 972 manufacturers
- CI 972 anhydrous
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- $3100.00
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2026-05-11
- CAS:115787-68-3
- Purity:
- Supply Ability: 10g
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| Product Name: | CI 972 | | Synonyms: | CI 972;CI 972 (anhydrous);2,6-Diamino-3,5-dihydro-7-(3-thienylmethyl)-4H-pyrrolo(3,2-D)pyrimidin-4-one | | CAS: | 115787-68-3 | | MF: | C11H12ClN5OS | | MW: | 297.76 | | EINECS: | | | Product Categories: | | | Mol File: | 115787-68-3.mol |  |
| | CI 972 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in DMSO |
| | CI 972 Usage And Synthesis |
| Uses | CI 972 anhydrous is a potent, orally active, and competitive inhibitor of purine nucleoside phosphorylase (PNP) (Ki=0.83 μM) under development as a T cell-selective immunosuppressive agent[1][2]. | | in vivo | CI 972 anhydrous (5-150 mg/kg; p.o.) produces dose-dependent elevation of plasma inosine one hour after administration to rats[1]. | | References | [1] Gilbertsen RB, et al. Biochemical and pharmacological properties of CI-972, a novel 9-deazaguanine analog purine nucleoside phosphorylase (PNP) inhibitor. Adv Exp Med Biol. 1991;309A:41-4. DOI:10.1007/978-1-4899-2638-8_8
[2] Gilbertsen RB,et al. Selective in vitro inhibition of human MOLT-4 T lymphoblasts by the novel purine nucleoside phosphorylase inhibitor, CI-972. Biochem Biophys Res Commun. 1991 Aug 15;178(3):1351-8. DOI:10.1016/0006-291x(91)91042-b |
| | CI 972 Preparation Products And Raw materials |
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