N-[(2-Chloro-6-fluorophenyl)methyl]-5-(1H-indazol-3-yl)-3-thiophenecarboxamide

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N-[(2-Chloro-6-fluorophenyl)methyl]-5-(1H-indazol-3-yl)-3-thiophenecarboxamide Basic information
Product Name:N-[(2-Chloro-6-fluorophenyl)methyl]-5-(1H-indazol-3-yl)-3-thiophenecarboxamide
Synonyms:N-[(2-Chloro-6-fluorophenyl)methyl]-5-(1H-indazol-3-yl)-3-thiophenecarboxamide;N-(2-Chloro-6-fluorobenzyl)-5-(1H-indazol-3-yl)thiophene-3-carboxamide;XMU-MP-9
CAS:2251130-41-1
MF:C19H13ClFN3OS
MW:385.84
EINECS:
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Mol File:2251130-41-1.mol
N-[(2-Chloro-6-fluorophenyl)methyl]-5-(1H-indazol-3-yl)-3-thiophenecarboxamide Structure
N-[(2-Chloro-6-fluorophenyl)methyl]-5-(1H-indazol-3-yl)-3-thiophenecarboxamide Chemical Properties
Boiling point 634.8±55.0 °C(Predicted)
density 1.444±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
pka13.05±0.40(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
N-[(2-Chloro-6-fluorophenyl)methyl]-5-(1H-indazol-3-yl)-3-thiophenecarboxamide Usage And Synthesis
UsesXMU-MP-9 is a bifunctional compound that binds to the C2 domain of Nedd4-1 and the allosteric site of K-Ras. XMU-MP-9 enhances the interaction between Nedd4-1 and K-Ras, induces conformational changes in the Nedd4-1/K-Ras complex, promotes the ubiquitination and degradation of multiple K-Ras mutants, and inhibits the proliferation of cells carrying K-Ras mutants. XMU-MP-9 can be used in cancer research[1].
References[1] Taoling Zeng, et al. "Targeting oncogenic K-Ras mutants with a small-molecule degrader through Nedd4-1."bioRxiv(2024): 2024-04.
N-[(2-Chloro-6-fluorophenyl)methyl]-5-(1H-indazol-3-yl)-3-thiophenecarboxamide Preparation Products And Raw materials
Tag:N-[(2-Chloro-6-fluorophenyl)methyl]-5-(1H-indazol-3-yl)-3-thiophenecarboxamide(2251130-41-1) Related Product Information
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