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| | 2-Amino-5-iodobenzotrifluoride Basic information |
| Product Name: | 2-Amino-5-iodobenzotrifluoride | | Synonyms: | 4-IODO-2-(TRIFLUOROMETHYL)ANILINE;ASISCHEM Z25859;2-Amino-5-iodobenzotrifluoride 98%;2-Amino-5-iodobenzotrifluoride98%;4-Iodo-2-(trifluoromethyl)aniline, 4-Iodo-alpha,alpha,alpha-trifluoro-o-toluidine;2-AMino-5-iodobenzotrifluoride[4-iodo-2-(trifluoroMethyl)aniline];2-amino-5-iodo-trifluoromethylbenzene;4-iodo-2-(trifluoromethyl)benzenamine | | CAS: | 97760-97-9 | | MF: | C7H5F3IN | | MW: | 287.02 | | EINECS: | | | Product Categories: | Phenyls & Phenyl-Het;Amines;Phenyls & Phenyl-Het | | Mol File: | 97760-97-9.mol |  |
| | 2-Amino-5-iodobenzotrifluoride Chemical Properties |
| Boiling point | 262℃ | | density | 1.948 | | Fp | 112℃ | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | form | liquid | | pka | 0.67±0.10(Predicted) | | color | Clear, brown |
| | 2-Amino-5-iodobenzotrifluoride Usage And Synthesis |
| Uses | 4-Iodo-2-trifluoromethylaniline | | Synthesis | The general procedure for synthesizing 2-amino-5-iodobenzotrifluoride from 1-(trifluoromethyl)-1,2-phenyliodonyl-3(1H)-one and p-iodoaniline is as follows: in this embodiment, p-iodoaniline was used as the aromatic amine, and the rest of the reaction conditions and post-processing steps were the same as in Example 28. The specific reaction conditions were as follows: 1-(trifluoromethyl)-1,2-phenyliodono-3(1H)-one (0.5 mmol, 1.0 eq.), p-iodoaniline (1.5 mmol, 3.0 eq.), nickel hydroxide (10 μmol), and potassium carbonate (1.5 mmol, 3.0 eq.) were used as bases, and DMSO (2 mL) was used as a solvent, and the temperature of the reaction was 35 °C. The reaction time was 2 hours. After the reaction was completed, post-treatment was carried out according to the method of Example 1. | | References | [1] Organic Letters, 2018, vol. 20, # 13, p. 3732 - 3735
[2] Patent: CN108503552, 2018, A. Location in patent: Paragraph 0240-0244
[3] Patent: CN103553857, 2016, B. Location in patent: Paragraph 0021-0022
[4] Organic Letters, 2014, vol. 16, # 6, p. 1768 - 1771 |
| | 2-Amino-5-iodobenzotrifluoride Preparation Products And Raw materials |
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