- PVM/MA
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2026-09-18
- CAS:00-00-0
- Purity: 0.99
- AKR1C3-IN-9
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- $41.00
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2026-07-27
- CAS:
- Purity: 99.98%
- Supply Ability: 10g
- ARUK2001607
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- $47.00
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2026-07-27
- CAS:2924824-56-4
- Purity: 99.86%
- Supply Ability: 10g
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| Product Name: | PVM/MA | | Synonyms: | PF06291874;E-7386;FM381 FM-381;6-(6-chloropyridin-2-yl)-N2,N4-bis((R)-1,1,1-trifluoropropan-2-yl)-1,3,5-triazine-2,4-diamine;PVM/MA;S-N-NITROSO-2-METHYLPIPERIDINE;PCB138/160;FLEABUSTERSRXPOWDER | | CAS: | 1644545-52-7 | | MF: | C14H13ClF6N6 | | MW: | 414.74 | | EINECS: | | | Product Categories: | api;Dimethoxyamphetamine | | Mol File: | 1644545-52-7.mol |  |
| | PVM/MA Chemical Properties |
| Boiling point | 467.5±55.0 °C(Predicted) | | density | 1.491±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml | | form | A crystalline solid | | pka | 1.49±0.41(Predicted) | | color | Light yellow to light brown | | InChI | InChI=1S/C14H13ClF6N6/c1-6(13(16,17)18)22-11-25-10(8-4-3-5-9(15)24-8)26-12(27-11)23-7(2)14(19,20)21/h3-7H,1-2H3,(H2,22,23,25,26,27)/t6-,7-/m1/s1 | | InChIKey | QCZAWDGAVJMPTA-RNFRBKRXSA-N | | SMILES | N1=C(C2=NC(Cl)=CC=C2)N=C(N[C@H](C)C(F)(F)F)N=C1N[C@H](C)C(F)(F)F |
| | PVM/MA Usage And Synthesis |
| Uses | PF-06291874 is a novel and potent glucagon receptor antagonist for the potential treatment of diabetes mellitus. PF-06291874, has a lower molcular weight and lipophilicity than historical glucagon receptor antagonists, resulting in excellent selectivity in broad-panel screening, lower cytotoxicity, and excellent overall in vivo safety in early pre-clinical testing. | | Synthesis | Maleic anhydride (MA) was added to a solvent mixture of cyclohexane and ethyl acetate in a polymerizer equipped with an agitator, a reflux condenser, and an inner temperature-controlling device. The polymerizer was purged of air and filled with nitrogen. The solution was heated to 70 °C, and then an initiator solution (lauroyl peroxide dissolved in ethyl acetate) and Methyl vinyl ether (MVE) were added to the polymerizer in a dropwise manner. A slurry was obtained, which was filtered and dried under a vacuum to obtain a white powdery copolymer. | | IC 50 | IDH1; IDH2 |
| | PVM/MA Preparation Products And Raw materials |
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