PCSK9-IN-23

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PCSK9-IN-23 Suppliers list
Company Name: Shanghai Beckham Medical Technology Co., Ltd  
Tel: 13816613772
Email: huahero21@sina.com
Company Name: Guangzhou Younan Technology Co., Ltd  
Tel: 020-82000279 18988941452
Email: YN_research@163.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
PCSK9-IN-23 Basic information
Product Name:PCSK9-IN-23
Synonyms:PCSK9-IN-23;2(1H)-Pyridinone, 6-methyl-1-[[4-(trifluoromethyl)phenyl]methyl]-4-[[[4-(trifluoromethyl)phenyl]methyl]amino]-
CAS:2115700-96-2
MF:C22H18F6N2O
MW:440.38
EINECS:
Product Categories:
Mol File:2115700-96-2.mol
PCSK9-IN-23 Structure
PCSK9-IN-23 Chemical Properties
Boiling point 513.5±50.0 °C(predicted)
density 1.36±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka1.74±0.20(predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
PCSK9-IN-23 Usage And Synthesis
UsesPCSK9-IN-23 (compound 5C) is a potent PCSK9 inhibitor. PCSK9-IN-23 blocks PCSK9 secretion from HepG2 cells, significantly increases LDL receptor (LDLR) expression[1].
References[1] Lisa Giannessi, et al. Identification of 4-amino-2-Pyridones as new potent PCSK9 inhibitors: From phenotypic hit discovery to in vivo tolerability. Eur J Med Chem. 2023 Dec 20:265:116063. DOI:10.1016/j.ejmech.2023.116063
PCSK9-IN-23 Preparation Products And Raw materials
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