RGH-122

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RGH-122 Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
RGH-122 Basic information
Product Name:RGH-122
Synonyms:RGH-122;Spiro[1,3-dioxolane-2,5′(6′H)-[4H][1,2,4]triazolo[4,3-a][1]benzazepine], 8′-chloro-1′-[trans-4-(2-pyridinyloxy)cyclohexyl]-
CAS:2355304-05-9
MF:C24H25ClN4O3
MW:452.93
EINECS:
Product Categories:
Mol File:2355304-05-9.mol
RGH-122 Structure
RGH-122 Chemical Properties
Boiling point 663.801±65.00 °C(Press: 760.00 Torr)(predicted)
density 1.477±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka3.519±0.10(predicted)
Safety Information
MSDS Information
RGH-122 Usage And Synthesis
UsesRGH-122 (compound 43) is an orally active, potent, selective, and hV1a receptor antagonist with Ki value of 0.3 nM and IC50 of 0.9 nM. RGH-122 showes microsomal stability with CLint value of 13/28/25 μL/min/mg[1].
References[1] Baska F, et al. Discovery and Characterization of RGH-122, a Potent, Selective, and Orally Bioavailable V1a Receptor Antagonist. J Med Chem. 2024 Jan 11;67(1):643-673. DOI:10.1021/acs.jmedchem.3c01868
RGH-122 Preparation Products And Raw materials
Tag:RGH-122(2355304-05-9) Related Product Information
(2S,4R)-1-[(R)-5-Chloro-1-(2,4-dimethoxy-benzenesulfonyl)-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-pyrrolidine-2-carboxylic acid dimethylamide Imidafenacin LIXIVAPTAN WAY-151932 Terlipressin Diacetate Salt 2-(3-Chloro-4-fluorophenyl)-N-(1-methylethyl)-6-[3-(4-morpholinyl)propoxy]-4-oxo-pyrido[2,3-d]pyrimidine-3(4H)-acetamide hydrochloride