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MedChemexpress LLC
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| Products Intro: |
Product Name:WAY-151932
CAS:220460-92-4
Purity:>98% Package:4900RMB/1mg
|
| Company Name: |
Shanghai Amico Chemicals Co. LTD
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微信 17321281695 18019252918 |
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| Products Intro: |
Product Name:VNA-932
CAS:220460-92-4
Purity:0.97 Package:1g;10g;100g
|
| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767 |
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sales@chemegen.com |
| Products Intro: |
Product Name:WAY-151932
CAS:220460-92-4
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
WAY-151932 manufacturers
- WAY-151932
-
- $396.00
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2026-08-08
- CAS:220460-92-4
- Purity: 97.84%
- Supply Ability: 10g
|
| | WAY-151932 Basic information |
| Product Name: | WAY-151932 | | Synonyms: | WAY-151932;VNA-932;Methanone, [2-chloro-4-(3-methyl-1H-pyrazol-1-yl)phenyl]-5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-yl-;WAY-VNA 932;WAY151932,WAY 151932;VNA-932 (WAY-151932) | | CAS: | 220460-92-4 | | MF: | C23H19ClN4O | | MW: | 402.88 | | EINECS: | | | Product Categories: | | | Mol File: | 220460-92-4.mol |  |
| | WAY-151932 Chemical Properties |
| Boiling point | 630.6±55.0 °C(Predicted) | | density | 1.33±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | pka | 0.04±0.12(Predicted) | | color | White to off-white |
| | WAY-151932 Usage And Synthesis |
| Uses | WAY-151932 is a vasopressin V2-receptor agonist with IC50 of 80.3 nM and 778 nM in human-V2 binding and V1a binding assay. | | Biological Activity | WAY-151932 is an antidiuretic hormone V2 receptor agonist with IC50 of 80.3 and 778 nM in human V2 and V1a binding assays, respectively. | | in vitro | WAY-151932 (VNA-932) stimulates cAMP formation in LV2 cells expressing the hV 2 receptors in a dose-dependent manner with an EC 50 of 0.74±0.07 nM. | | in vivo | Oral administration of WAY-151932 (VNA-932) to water-loaded conscious rats produces a dose-dependent decrease in urine volume (ED 50 =0.14 mg/kg, 2.5% starch in water vehicle) and a corresponding increase in osmolality without altering the urine electrolyte excretion profile. | | target | IC50: 80.3 nM (human-V2 binding), 778 nM (human-V1a binding) | | References | [1] Molinari AJ, et al. Identification and synthesis of major metabolites of Vasopressin V2-receptor agonist WAY-151932, and antagonist, Lixivaptan. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5796-800. DOI:10.1016/j.bmcl.2007.08.053
[2] Failli AA, et al. Pyridobenzodiazepines: a novel class of orally active, vasopressin V2 receptor selective agonists. Bioorg Med Chem Lett. 2006 Feb 15;16(4):954-9. DOI:10.1016/j.bmcl.2005.10.107 |
| | WAY-151932 Preparation Products And Raw materials |
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