| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
- PG01
-
- $53.00
-
2026-05-23
- CAS:853138-65-5
- Purity: 99.87%
- Supply Ability: 10g
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| | Phenylglycine-01 Basic information |
| Product Name: | Phenylglycine-01 | | Synonyms: | N-Methyl-N-[2-[[4-(1-Methylethyl)phenyl]amino]-2-1H-indole-3-acetamide;PG 01;2-[(2-1H-indol-3-yl-acetyl)-methylamino]-N-(4-isopropylphenyl)-2-phenylacetamide;N-Methyl-N-[2-[[4-(1-methylethyl)phenyl]amino]-2-oxo-1-phenylethyl]-1H-indole-3-acetamide;1H-Indole-3-acetamide, N-methyl-N-[2-[[4-(1-methylethyl)phenyl]amino]-2-oxo-1-phenylethyl]-;PG-01 >=98% (HPLC);PG-01,PG01;PG01, 10 mM in DMSO | | CAS: | 853138-65-5 | | MF: | C28H29N3O2 | | MW: | 439.55 | | EINECS: | | | Product Categories: | | | Mol File: | 853138-65-5.mol |  |
| | Phenylglycine-01 Chemical Properties |
| Boiling point | 704.6±60.0 °C(Predicted) | | density | 1.217±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: ≥10mg/mL | | form | powder | | pka | 13.31±0.70(Predicted) | | color | white to off-white |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | 3 |
| | Phenylglycine-01 Usage And Synthesis |
| Uses | PG01 is a potent CFTR Cl- channel potentiator. PG01 can correct gating defects of CFTR mutants, is effective on b>E193K, G970R and G551D (CFTR mutants) with Kd values of 0.22 μM, 0.45 μM and 1.94 μM, respectively. PG01 is also effective on ΔF508 (Ka of 0.3 μM). PG01 increases ΔF508-CFTR Cl- current after adding Forskolin[1][2]. | | in vivo | Pharmacokinetic analysis of PG01 in rats is done by serial measurements of plasma concentrations after single bolus infusions (5 mg/kg). PG01 pharmacokinetics fitted a two-compartment model with half-times of ＜5 min and 130 min with volume of distribution 4 L. Microsome metabolism studies and rat pharmacokinetic analysis suggests significantly more rapid metabolism of PG01 than SF-03[1]. | | References | [1] Pedemonte N, et al. Phenylglycine and sulfonamide correctors of defective delta F508 and G551D cystic fibrosis transmembrane conductance regulator chloride-channel gating. Mol Pharmacol. 2005 May;67(5):1797-807. DOI:10.1124/mol.105.010959
[2] Caputo A, et al. Mutation-specific potency and efficacy of cystic fibrosis transmembrane conductance regulator chloride channel potentiators. J Pharmacol Exp Ther. 2009 Sep;330(3):783-91. DOI:10.1124/jpet.109.154146 |
| | Phenylglycine-01 Preparation Products And Raw materials |
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