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| | KT D606 Basic information |
| Product Name: | KT D606 | | Synonyms: | KT D606;9,12-Epoxy-1H-diindolo[1,2,3-fg:3′,2′,1′-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, 3,3′-(1,7-heptanediyl)bis[2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, (9S,9′S,10R,10′R,12R,12′R)- | | CAS: | 1429063-06-8 | | MF: | C59H50N6O10 | | MW: | 1003.06 | | EINECS: | | | Product Categories: | | | Mol File: | 1429063-06-8.mol |  |
| | KT D606 Chemical Properties |
| density | 1.71±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | | pka | 3.03±0.60(predicted) |
| | KT D606 Usage And Synthesis |
| Uses | KT D606 is an inhibitor of the PAK kinase family, with an IC50 value of 4 μM. KT D606 selectively blocks the proliferation of cancer cells transformed by oncogenic RAS mutants and can be used for research on RAS/PAK1-induced cancers[1]. | | References | [1] Nheu TV, et al. The K252a derivatives, inhibitors for the PAK/MLK kinase family selectively block the growth of RAS transformants. Cancer J. 2002 Jul-Aug;8(4):328-36. DOI:10.1097/00130404-200207000-00009 |
| | KT D606 Preparation Products And Raw materials |
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