BHA536

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BHA536 Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
BHA536 Basic information
Product Name:BHA536
Synonyms:BHA536;1H-Pyrrole-2,5-dione, 3-[2-chloro-7-[(dimethylamino)methyl]-1-naphthalenyl]-4-[7-[2-(2-methoxyethoxy)ethoxy]-1H-indol-3-yl]-
CAS:919992-85-1
MF:C30H30ClN3O5
MW:548.03
EINECS:
Product Categories:
Mol File:919992-85-1.mol
BHA536 Structure
BHA536 Chemical Properties
Boiling point 758.333±60.00 °C(Press: 760.00 Torr)(predicted)
density 1.326±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka7.029±0.60(predicted)
Safety Information
MSDS Information
BHA536 Usage And Synthesis
UsesBHA536 is an orally active selective inhibitor for PKCα/β and NF-kB signaling pathway. BHA536 inhibits the proliferation of CD79-mutated ABC DLBCL cell, arrests cell cycle at G1 phase, and induces apoptosis in TMD8 cell. BHA536 exhibits antitumor efficacy in mice[1].
References[1] Naylor TL, et al., Protein kinase C inhibitor sotrastaurin selectively inhibits the growth of CD79 mutant diffuse large B-cell lymphomas. Cancer Res. 2011 Apr 1;71(7):2643-53. DOI:10.1158/0008-5472.CAN-10-2525
BHA536 Preparation Products And Raw materials
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