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| | [N-(9-Fluorenylmethoxycarbonyl)-N-decylamino]ethanal Basic information |
| Product Name: | [N-(9-Fluorenylmethoxycarbonyl)-N-decylamino]ethanal | | Synonyms: | 2-[N-(9-FluorenylMethoxycarbonyl)-N-decylaMino]ethanal;Decyl(2-oxoethyl)-carbaMic Acid 9H-Fluoren-9-ylMethyl Ester;N-Decyl-N-(2-oxoethyl)-9H-fluoren-9-ylMethyl Ester;9H-fluoren-9-ylmethyl N-decyl-N-(2-oxoethyl)carbamate;(9H-fluoren-9-yl)methyl decylformylmethylcarbamate;Carbamic acid, N-decyl-N-(2-oxoethyl)-, 9H-fluoren-9-ylmethyl ester;(9H-Fluoren-9-yl)methyl decyl(2-oxoethyl)carbamate;[N-(9-FLUORENYLMETHOXYCARBONYL)-N-DECYLAMINO]ETHANA | | CAS: | 239088-22-3 | | MF: | C27H35NO3 | | MW: | 421.57 | | EINECS: | | | Product Categories: | Telavancin intermediate;Amines;Aromatics | | Mol File: | 239088-22-3.mol | ![[N-(9-Fluorenylmethoxycarbonyl)-N-decylamino]ethanal Structure](CAS/GIF/239088-22-3.gif) |
| | [N-(9-Fluorenylmethoxycarbonyl)-N-decylamino]ethanal Chemical Properties |
| Boiling point | 550.6±29.0 °C(Predicted) | | density | 1.075±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Store in freezer, under -20°C | | solubility | Chloroform (Slightly), DMSO (Very Slightly, Heated), Ethyl Acetate (Slightly) | | pka | -1.80±0.70(Predicted) | | form | Gel | | color | Pale Yellow to Orange |
| | [N-(9-Fluorenylmethoxycarbonyl)-N-decylamino]ethanal Usage And Synthesis |
| Chemical Properties | Oil | | Uses | [N-(9-Fluorenylmethoxycarbonyl)-N-decylamino]ethanal is used in the preparation of vancomycin-related antibacterial agents. | | Synthesis | The general procedure for the synthesis of N-Fmoc-N-(2-oxoethyl)decylamine from the compound (CAS:1260529-12-1) was as follows: the pale yellow liquid 10 obtained from the above reaction was dissolved in dichloromethane (300 mL) and cooled to -10 °C. 37% hydrochloric acid (77 g, 0.75 mol) was slowly added dropwise under a tightly controlled temperature range (-10 to -20°C). After the dropwise addition, the reaction mixture was stirred at 10 °C (temperature range 10 to 30 °C) for 4 hours (time range 2 to 4 hours). Upon completion of the reaction, the reaction was neutralized by slow addition of 5% sodium bicarbonate solution (300 mL). The organic and aqueous layers were separated and the organic layer was dried with anhydrous sodium sulfate. The organic phase was concentrated under reduced pressure and the resulting residue was recrystallized from n-heptane to give a white solid product, 9H-fluorene-9-methyl decyl (2-oxoethyl) carbamate (20.3 g, 82.2% yield). | | References | [1] Patent: CN106631902, 2017, A. Location in patent: Paragraph 0034; 0037; 0038
[2] Patent: WO2011/5959, 2011, A1. Location in patent: Page/Page column 23-24
[3] Patent: WO2011/5959, 2011, A1 |
| | [N-(9-Fluorenylmethoxycarbonyl)-N-decylamino]ethanal Preparation Products And Raw materials |
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