H-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2 manufacturers
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| | H-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2 Basic information |
| Product Name: | H-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2 | | Synonyms: | PACAP 1-38;PACAP (31-38) (HUMAN, OVINE, RAT);PACAP-38 (31-38) (HUMAN, CHICKEN, MOUSE, OVINE, PORCINE, RAT);PITUITARY ADENYLATE CYCLASE ACTIVATING PEPTIDE (31-38), HUMAN, OVINE, RAT;PITUITARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE (31-38) (HUMAN, OVINE, RAT);PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE 1-38;PITUITARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE-38 (31-38) (HUMAN, CHICKEN, MOUSE, OVINE, PORCINE, RAT);TYR-LYS-GLN-ARG-VAL-LYS-ASN-LYS-NH2 | | CAS: | 138764-85-9 | | MF: | C47H83N17O11 | | MW: | 1062.27 | | EINECS: | | | Product Categories: | | | Mol File: | 138764-85-9.mol |  |
| | H-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2 Chemical Properties |
| density | 1.44±0.1 g/cm3(Predicted) | | storage temp. | -15°C | | pka | 9.96±0.15(Predicted) | | form | Solid | | color | White to off-white | | Sequence | Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2 |
| | H-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2 Usage And Synthesis |
| Uses | PACAP-38 (31-38), human, mouse, rat is a PAC1 receptor activator and increases the α-secretase activity. PACAP-38 (31-38), human, mouse, rat elevates cytosolic Ca2+, increases proliferation and increases phosphorylation of extracellular regulates kinase (ERK) and the epidermal growth factor receptor (EGFR). PACAP-38 (31-38), human, mouse, rat demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. PACAP-38 (31-38), human, mouse, rat can be used for neurotrophic and neuroprotective research[1][2][3]. | | Biological Activity | Endogenous neuropeptide showing considerable homology with vasoactive intestinal peptide (VIP) but with a greater potency for stimulation of adenylyl cyclase. | | References | [1] Moody TW, et, al. PAC1 regulates receptor tyrosine kinase transactivation in a reactive oxygen species-dependent manner. Peptides. 2019 Oct;120:170017. DOI:10.1016/j.peptides.2018.09.005
[2] Kojro E, et, al. The neuropeptide PACAP promotes the alpha-secretase pathway for processing the Alzheimer amyloid precursor protein. FASEB J. 2006 Mar;20(3):512-4. DOI:10.1096/fj.05-4812fje
[3] Braas KM, et, al. Pituitary adenylate cyclase-activating polypeptides, PACAP-38 and PACAP-27, regulation of sympathetic neuron catecholamine, and neuropeptide Y expression through activation of type I PACAP/VIP receptor isoforms. Ann N Y Acad Sci. 1996 De DOI:10.1111/j.1749-6632.1996.tb17484.x |
| | H-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2 Preparation Products And Raw materials |
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