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| | Methyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate Basic information |
| Product Name: | Methyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate | | Synonyms: | Methyl 4-nitro-1-methylimidazole-2-carboxylate;Methyl -methyl-4-nitro-1H-imidazole-2-carboxylate;Methyl 1-Methyl-4-nitroimidazole-2-carboxylate;1H-Imidazole-2-carboxylic acid, 1-methyl-4-nitro-, methyl ester;3-BROMO-10-CHLOROPHENOL;Carbamicacid,N-[2-(2-bromoethoxy)ethyl]-,1,6-dimethylethylester;Methyl 1-methyl-4-nitro-1H-imidazol-2-carboxylate;Methyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate | | CAS: | 169770-25-6 | | MF: | C6H7N3O4 | | MW: | 185.14 | | EINECS: | | | Product Categories: | | | Mol File: | 169770-25-6.mol |  |
| | Methyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate Chemical Properties |
| Melting point | 157-158 °C | | Boiling point | 345.0±34.0 °C(Predicted) | | density | 1.49±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | -2.47±0.60(Predicted) | | Appearance | White to off-white Solid |
| HazardClass | IRRITANT | | HS Code | 2933299090 |
| | Methyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of methyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate from methanol and 2,2,2-trichloro-1-(1-methyl-4-nitro-1H-imidazol-2-yl)ethanone was as follows: methanol (40 mL) was added to a reaction flask containing 2,2,2-trichloro-1-(1-methyl-4-nitro-1H-imidazol-2-yl)ethanone, heated to 40 °C and stirred for 10 minutes. Subsequently, a small amount of sodium hydride (100 mg) was added to the reaction mixture to ensure complete methanolysis. After continued stirring for 2 h, the reaction mixture was filtered to afford methyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate in 94% yield. The product was confirmed by 1H-NMR (CDCl3): δ 7.84 (s, 1H, Im-CH), 4.18 (s, 3H, CH3), 3.93 (s, 3H, CH3).EI-HRMS analysis resulted in a m/z calculated value of 185.0437 for C6H7N3O4 and a measured value of 185.0476 (100%). | | References | [1] Patent: WO2007/45096, 2007, A1. Location in patent: Page/Page column 45; 86
[2] Heterocycles, 1995, vol. 41, # 6, p. 1181 - 1196
[3] Synthetic Communications, 2004, vol. 34, # 9, p. 1609 - 1615 |
| | Methyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate Preparation Products And Raw materials |
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