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| | Triphenylphosphine hydrobromide Basic information |
| Product Name: | Triphenylphosphine hydrobromide | | Synonyms: | TPH;TRIPHENYLPHOSPHINE HYDROBROMIDE;TRIPHENYLPHOSPHONIUM BROMIDE;Phosphine, triphenyl-, hydrobromide;Triphenylphosphine hydrobromide 97%;Triphenylphosphoniumbromide,99.9%;Phosphine, triphenyl-, compd. with hydrobromic acid;Triphenylphosphonium bromide,99% | | CAS: | 6399-81-1 | | MF: | C18H16BrP | | MW: | 343.2 | | EINECS: | 229-012-6 | | Product Categories: | bc0001 | | Mol File: | 6399-81-1.mol |  |
| | Triphenylphosphine hydrobromide Chemical Properties |
| Melting point | 196 °C (dec.) (lit.) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Crystalline Powder or Chunks | | color | White to light beige | | biological source | rabbit | | Water Solubility | Soluble in water. | | BRN | 3633387 | | InChI | InChI=1S/C18H15P.BrH/c1-4-10-16(11-5-1)19(17-12-6-2-7-13-17)18-14-8-3-9-15-18;/h1-15H;1H | | InChIKey | CMSYDJVRTHCWFP-UHFFFAOYSA-N | | SMILES | P(C1C=CC=CC=1)(C1C=CC=CC=1)C1=CC=CC=C1.Br | | CAS DataBase Reference | 6399-81-1(CAS DataBase Reference) |
| Hazard Codes | C,Xi | | Risk Statements | 22-34-36/37/38 | | Safety Statements | 26-36/37/39-45-36 | | RIDADR | UN 3261 8/PG 3 | | WGK Germany | 3 | | Hazard Note | Corrosive | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 29310095 |
| | Triphenylphosphine hydrobromide Usage And Synthesis |
| Chemical Properties | white to light beige crystalline powder or chunks | | Uses | Triphenylphosphine hydrobromide is the hydrobromide salt of Triphenylphosphine, used in the preparation of uridine derivatives as substrate donor analogs of UDP-sugars for glycosyltransferases. Also used in the preparation of tensioactive and antibacterial deoxyglycoside compounds via catalysis. | | Uses | Triphenylphosphine hydrobromide is used as mild source of anhydrous HBr; catalyst for formation of THP ethers from tertiary alcohols; preparation of phosphonium salts. | | reaction suitability | reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling | | Synthesis | The Preparative Method of Triphenylphosphine Hydrobromide: addition of anhydrous Hydrogen Bromide to an ethereal solution of Triphenylphosphine; addition of Ph3P to 48% aqueous HBr followed by CHCl3 extraction and drying.
| | References | [1] Patent: US2018/170889, 2018, A1. Location in patent: Paragraph 0317
[2] Tetrahedron Letters, 2013, vol. 54, # 51, p. 7031 - 7034
[3] Patent: JP6210065, 2017, B2. Location in patent: Paragraph 0134
[4] Synthesis, 1988, # 2, p. 157 - 158
[5] Angewandte Chemie - International Edition, 2016, vol. 55, # 19, p. 5846 - 5850 |
| | Triphenylphosphine hydrobromide Preparation Products And Raw materials |
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