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| | MMP substrate III, fluorogenic Basic information |
| Product Name: | MMP substrate III, fluorogenic | | Synonyms: | DABCYL-(GAMMA-ABU)-PQGL-E(EDANS)AK-NH2;DABCYL-GAMMA-ABU-PRO-GLN-GLY-LEU-GLU(EDANS)-ALA-LYS-NH2;DABCYL-GABA-PQGL-E(EDANS)-AK-NH2;DABCYL-GABA-PRO-GLN-GLY-LEU-GLU(EDANS)-ALA-LYS-NH2;DABCYL-(G-ABU)-PQGL-E(EDANS)AK-NH2;DABCYL-(G-ABU)-PRO-GLN-GLY-LEU-GLU(EDANS)-ALA-LYS-NH2;DABCYL-γ-Abu-PQGL-Glu(EDANS)-AK-NH2;TNO211 | | CAS: | 193475-71-7 | | MF: | C63H88N16O14S | | MW: | 1325.54 | | EINECS: | | | Product Categories: | peptide | | Mol File: | 193475-71-7.mol |  |
| | MMP substrate III, fluorogenic Chemical Properties |
| density | 1.40±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMSO: soluble
Tris-buffered saline, pH 7.6: soluble | | pka | -0.26±0.40(Predicted) | | form | lyophilized solid | | color | red | | Sequence | {DABCYL-GABA}-Pro-Gln-Gly-Leu-Glu-{EDANS}-Ala-Lys-NH2 |
| WGK Germany | WGK 1 | | Storage Class | 11 - Combustible Solids |
| | MMP substrate III, fluorogenic Usage And Synthesis |
| Uses | TNO211 is a biological active peptide. (Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.This peptide is a highly soluble fluorogenic MMP substrate for MMP-2, 8, 12, 13 and 14, containing the MMP cleavable Gly-Leu bond and EDANS/DABCYL. Fluorogenic assays using TNO211 are sensitive and can detect MMP activity in culture medium from endothelial cells and untreated synovial fluid from patients. Abs/Em = 340/490 nm.) | | Biological Activity | Cell permeable: no', 'Primary Target
Detection of MMP activity', 'Product does not compete with ATP.', 'Reversible: no |
| | MMP substrate III, fluorogenic Preparation Products And Raw materials |
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