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4,4'-Sulfonylbis(2-methylphenol)

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4,4'-Sulfonylbis(2-methylphenol) Basic information
Product Name:4,4'-Sulfonylbis(2-methylphenol)
Synonyms:3,3'-DIMETHYL-4,4'-DIHYDROXYDIPHENYL SULFONE;4,4'-Dihydroxy-3,3'-dimethyl[sulfonylbisbenzene];Phenol, 4,4'-sulfonylbis[2-methyl-;4,4'-Sulfonylbis(2-methylphenol);4,4'-Sulfonylbis(2-methylphenol);Topoisomerase IIα-IN-9
CAS:16346-97-7
MF:C14H14O4S
MW:278.32
EINECS:
Product Categories:Bisphenol and Sulfonyldiphenol Monomers;Monomers;Polymer Science
Mol File:16346-97-7.mol
4,4'-Sulfonylbis(2-methylphenol) Structure
4,4'-Sulfonylbis(2-methylphenol) Chemical Properties
Melting point 273-276 °C(lit.)
Boiling point 518.8±50.0 °C(Predicted)
density 1.343±0.06 g/cm3(Predicted)
solubility DMSO (Slightly), Methanol (Slightly, Heated)
form Solid
pka7.25±0.20(Predicted)
color Pale Orange to Pale Red
InChI1S/C14H14O4S/c1-9-7-11(3-5-13(9)15)19(17,18)12-4-6-14(16)10(2)8-12/h3-8,15-16H,1-2H3
InChIKeyXTEGBRKTHOUETR-UHFFFAOYSA-N
SMILESCc1cc(ccc1O)S(=O)(=O)c2ccc(O)c(C)c2
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
Storage Class11 - Combustible Solids
Hazard ClassificationsEye Irrit. 2
Skin Irrit. 2
STOT SE 3
MSDS Information
ProviderLanguage
SigmaAldrich English
4,4'-Sulfonylbis(2-methylphenol) Usage And Synthesis
UsesTopoisomerase IIα-IN-9 (NSC85582) is a bisphenol compound that has a moderate inhibitory effect on DNA topoisomerase Topoisomerase II (IC50: 571 μM). Topoisomerase IIα-IN-9 also exhibits a certain cell growth inhibitory effect, with IC50s of 117 μM and 218 μM for K562 and CHO, respectively[1].
References[1] A Three-Dimensional Quantitative Structure-Activity Analysis of a New Class of Bisphenol Topoisomerase II Inhibitors
4,4'-Sulfonylbis(2-methylphenol) Preparation Products And Raw materials
Preparation Products3,3'-Diamino-4,4'-dihydroxydiphenyl sulfone
Tag:4,4'-Sulfonylbis(2-methylphenol)(16346-97-7) Related Product Information
Bis(4-hydroxyphenyl) Sulfone 4,4'-Thiobis-phenol Bis(4-hydroxy-3,5-dimethylphenyl) sulfone 4,4'-Sulfonylbis(2-methylphenol) 4-Methylthio-ortho-cresol Bis(4-hydroxy-3-methylphenyl) sulfide 3-Methyldiphenylsulfide 4-((3,5-Dimethyl-4-[(2,3,3-trichloroacryloyl)oxy]phenyl)sulfonyl)-2,6-dimethylphenyl 2,3,3-trichloroacrylate 4-((4-[(3-Chloro-2,2-dimethylpropanoyl)oxy]-3,5-dimethylphenyl)sulfonyl)-2,6-dimethylphenyl 3-chloro-2,2-dimethylpropanoate 3,3'-Sulfonylbis(6-methylphenol) 3,3'-Sulfonylbis(5-methylphenol) 4,4'-Sulfonylbis(3-methylphenol) 2,2'-Sulfonylbis(6-methylphenol) 2,2'-Sulfonylbis(5-methylphenol) 3,3'-Sulfonylbis(4-methylphenol) 3,3'-Sulfonylbis(2-methylphenol) 2,2'-Sulfonylbis(4-methylphenol) 2,2'-Sulfonylbis(3-methylphenol)