| Company Name: |
BOC Sciences |
| Tel: |
16314854226; +8616314854226 |
| Email: |
inquiry@bocsci.com |
|
| | PLEVITREXED Basic information |
| Product Name: | PLEVITREXED | | Synonyms: | (Rac)-BGC9331;(Rac)-Plevitrexed;(Rac)-ZD 9331;2H-Tetrazole-5-butanoic acid, α-[[4-[[(3,4-dihydro-2,7-dimethyl-4-oxo-6-quinazolinyl)methyl]-2-propyn-1-ylamino]-2-fluorobenzoyl]amino]-;(Rac)Plevitrexed,(Rac) Plevitrexed | | CAS: | 153538-08-0 | | MF: | C26H25FN8O4 | | MW: | 532.53 | | EINECS: | | | Product Categories: | | | Mol File: | 153538-08-0.mol |  |
| | PLEVITREXED Chemical Properties |
| density | 1.44±0.1 g/cm3(Predicted) | | pka | 3.35±0.10(Predicted) |
| | PLEVITREXED Usage And Synthesis |
| Uses | (Rac)-Plevitrexed ((Rac)-ZD 9331; (Rac)-BGC9331)is a racemate of Plevitrexed. Plevitrexed is an orally active and potent thymidylate synthase (TS) inhibitor. (Rac)-Plevitrexed is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | References | [1] Tochowicz A, et al. Development and binding mode assessment of N-[4-[2-propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-l-γ-glutamyl-D-glutamic acid (BGC 945), a novel thymidylate synthase inhibitor that targets tumor cells. J Med Chem.2013Jul 11;56(13):5446-55. DOI:10.1021/jm400490e |
| | PLEVITREXED Preparation Products And Raw materials |
|