2-Methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione

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2-Methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione manufacturers

  • Ryuvidine
  • Ryuvidine pictures
  • $61.00
  • 2026-07-27
  • CAS:265312-55-8
  • Purity: 99.32%
  • Supply Ability: 10g
2-Methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione Basic information
Product Name:2-Methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione
Synonyms:RYUVIDINE;Cdk4 Inhibitor III;2-methyl-5-(4-methylanilino)-1,3-benzothiazole-4,7-dione;4,7-Benzothiazoledione, 2-methyl-5-[(4-methylphenyl)amino]-;2-methyl-5-[(4-methylphenyl)amino]benzothiazole-4,7-dione;2-Methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione
CAS:265312-55-8
MF:C15H12N2O2S
MW:284.33
EINECS:
Product Categories:
Mol File:265312-55-8.mol
2-Methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione Structure
2-Methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione Chemical Properties
Boiling point 463.8±45.0 °C(Predicted)
density 1.416±0.06 g/cm3(Predicted)
storage temp. Store at +4°C
solubility Soluble to 20 mM in DMSO and to 5 mM in ethanol
form Black-purple solid
pka-1.63±0.20(Predicted)
color Brown to black
InChIInChI=1S/C15H12N2O2S/c1-8-3-5-10(6-4-8)17-11-7-12(18)15-13(14(11)19)16-9(2)20-15/h3-7,17H,1-2H3
InChIKeyHFPLHASLIOXVGS-UHFFFAOYSA-N
SMILESC12N=C(SC=1C(=O)C=C(NC1C=CC(C)=CC=1)C2=O)C
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
MSDS Information
2-Methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione Usage And Synthesis
UsesRyuvidine is an antifungal agent used against pathogenic fungi.
DefinitionChEBI: 2-methyl-5-(4-methylanilino)-1,3-benzothiazole-4,7-dione is an aminotoluene.
General DescriptionA cell-permeable dioxobenzothiazole compound that acts a selective Cdk4 inhibitor (IC50 = 6.0 μM for Cdk4/D1 and >200 μM for Cdk2/A). Exhibit better cytotoxic potential against cancer cells (IC50 = 0.61, 1.08, 0.30, and 1.21 μg/ml against A 549, Col 1, HL-60, and HepG2 tumor cells, respectively) than Cisplatin (Cat. No. 232120).
Biological ActivityCyclin-dependent kinase (cdk) 4 inhibitor (IC 50 = 6.0 μ M at cdk4/cyclin D1) that displays > 33-fold selectivity over cdk2 (IC 50 > 200 μ M at cdk2/cyclin A). Cytotoxic against a range of human cancer cells (IC 50 values are 0.30, 0.61, 1.08 and 1.21 μ g/mL for HL-60, A549, Col 1 and HepG2 cells respectively).
Biochem/physiol ActionsCell permeable: yes
storageStore at +4°C
2-Methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione Preparation Products And Raw materials
Tag:2-Methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione(265312-55-8) Related Product Information
2-Methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione 4,5-Thiazoledicarboxaldehyde 1-(2-Methyl-1,3-thiazol-4-yl)ethanone 4,7-Benzothiazoledione, 5-[[2-(dimethylamino)ethyl]amino]-2-methyl- EPZ004777 (formate) 4-Hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione