- HDH-PHARMA 26173
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2025-04-04
- CAS:871836-51-0
- Min. Order: 25KG
- Purity: 97%
- Supply Ability: 1tone
- HDH-PHARMA 26173
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- $1.00
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2019-07-06
- CAS:871836-51-0
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 200kg
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| | HDH-PHARMA 26173 Basic information |
| Product Name: | HDH-PHARMA 26173 | | Synonyms: | HDH-PHARMA 26173;EOS-61542;1H-Pyrazolo[4,3-c]pyridine,4-chloro-;4-chloro-1H-pyrazolo[4,3-c]pyridin-6-aMine;4-chloro-1H-pyrazolo[4;4-Chloro-1H-pyrazolo[4,3-...;4-Chloro-1H-pyrazolo[4,3-c]pyridine 98%;100182 | | CAS: | 871836-51-0 | | MF: | C6H4ClN3 | | MW: | 153.57 | | EINECS: | 937-467-3 | | Product Categories: | Heterocycle-Pyridine series | | Mol File: | 871836-51-0.mol |  |
| | HDH-PHARMA 26173 Chemical Properties |
| Boiling point | 357.5±22.0 °C(Predicted) | | density | 1.531 | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | form | solid | | pka | 10.46±0.40(Predicted) | | Appearance | White to light yellow Solid | | InChI | InChI=1S/C6H4ClN3/c7-6-4-3-9-10-5(4)1-2-8-6/h1-3H,(H,9,10) | | InChIKey | FUXZQGSDRGDYGX-UHFFFAOYSA-N | | SMILES | C1(Cl)=NC=CC2NN=CC1=2 |
| WGK Germany | WGK 3 | | HS Code | 2933399990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | HDH-PHARMA 26173 Usage And Synthesis |
| Uses | 4-Chloro-1H-pyrazolo[4,3-c]pyridine is used to prepare gp120-CD4 inhibitors. | | Synthesis | General procedure for the synthesis of 4-chloro-1H-pyrazolo[4,3-c]pyridine using 2,4-dichloronicotinaldehyde as starting material: intermediate 1 (1.7 g, 9.7 mmol) was dissolved in dimethoxyethane (12 ml) at room temperature, followed by addition of hydrazine monohydrate (1.2 ml, 38.6 mmol). The reaction mixture was stirred at 75°C overnight. Upon completion of the reaction, the mixture was concentrated to dryness and the resulting crude product was purified by fast chromatography using 20% to 100% ethyl acetate/petroleum ether gradient elution to afford the target product, 4-chloro-1H-pyrazolo[4,3-c]pyridine, as a white solid (0.82 g, 56% yield). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 7.60 (d, J = 6.9 Hz, 1H), 8.14 (d, J = 6.0 Hz, 1H), 8.32 (s, 1H); mass spectra (ES + APCI)+: m/z 154 [M + H]+. | | References | [1] Patent: WO2012/38743, 2012, A1. Location in patent: Page/Page column 82
[2] Patent: WO2010/106333, 2010, A1. Location in patent: Page/Page column 78-79
[3] Patent: WO2016/37578, 2016, A1. Location in patent: Page/Page column 118
[4] Patent: EP2857400, 2015, A1. Location in patent: Paragraph 1032
[5] Patent: WO2015/58084, 2015, A1. Location in patent: Paragraph 0403 |
| | HDH-PHARMA 26173 Preparation Products And Raw materials |
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