N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride

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N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride manufacturers

  • PHA 543613
  • PHA 543613 pictures
  • 2026-07-10
  • CAS:478149-53-0
  • Min. Order: 1KG
  • Purity: 98%
  • Supply Ability: 20Tons
  • PHA 543613
  • PHA 543613 pictures
  • $46.00
  • 2026-05-25
  • CAS:478149-53-0
  • Purity: 99.96%
  • Supply Ability: 10g
N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride Basic information
Product Name:N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride
Synonyms:PHA-543,613 - CAS 478149-53-0 - Calbiochem;N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamidehydrochloride;PHA 543613 hydrochloride;PHA-543613;(R)-N-(quinuclidin-3-yl)furo[2,3-c]pyridine-5-carboxaMide;N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxaMide hydrochlorid;N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide;N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]furo[2,3-c]pyridine-5-carboxamide
CAS:478149-53-0
MF:C15H17N3O2
MW:271.31
EINECS:
Product Categories:
Mol File:478149-53-0.mol
N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride Structure
N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride Chemical Properties
Melting point 313-315 °C
Boiling point 508.0±40.0 °C(Predicted)
density 1.32±0.1 g/cm3(Predicted)
storage temp. Store at +4°C
solubility DMSO: ≥20mg/mL
form White powder
pka12.19±0.20(Predicted)
color white to off-white
InChI1S/C15H17N3O2/c19-15(12-7-11-3-6-20-14(11)8-16-12)17-13-9-18-4-1-10(13)2-5-18/h3,6-8,10,13H,1-2,4-5,9H2,(H,17,19)/t13-/m0/s1
InChIKeyIPKZCLGGYKRDES-ZDUSSCGKSA-N
SMILESO=C(N[C@H]1CN2CC[C@H]1CC2)c3cc4ccoc4cn3
Safety Information
WGK Germany 1
Storage Class11 - Combustible Solids
MSDS Information
N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride Usage And Synthesis
UsesPHA-543613 has been used to study its effect on recognition memory and neurovascular coupling (NVC) response in β-amyloid (Aβ) 25-35-treated mice. It has also been used to study its effect on Aβ25-35-induced receptor alteration and cognitive impairment in mice.
DefinitionChEBI: Pha-543613 is a phosphoramide and an organothiophosphorus compound.
Biological ActivityPrimary Target
α7 nAChR
in vivo

PHA-543613 (0.3 mg/kg) successfully reverses Scopolamine-induced short-term memory deficits in rats[2]. PHA-543613 (4 and 12 mg/kg; i.p. once) reduces behavioral deficits and brain edema[3].

Animal Model:Male CD-1 mice with (intracerebral hemorrhage) ICH-induction or sham surgery[3]
Dosage:4 and 12 mg/kg
Administration:Intraperitoneal injection; 4 and 12 mg/kg; 1 hour after surgery
Result:Increased p-Akt and decreased p-GSK-3 and CC3 expressions in the ipsilateral hemisphere and reduced the neuronal cell death in the perihematomal area. Attenuated behavioral deficits and brain edema at 72 hours after ICH.
N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride Preparation Products And Raw materials
Tag:N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3- c]pyridine- 5-carboxamide hydrochloride PHA 543613 hydrochloride(478149-53-0) Related Product Information
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